Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
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DOI：
10.1016/j.bmcl.2012.05.098
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发表时间：
2012-07-15
影响因子：
2.7
通讯作者：
Zheng, Xiaolan
中科院分区：
文献类型：
--
作者：
Dakin, Les A.;Block, Michael H.;Zheng, Xiaolan
新型取代亚苄基-1,3-噻唑烷-2,4-二酮 (TZD) 已被确定为有效且高度选择性的 PIM 激酶抑制剂。描述了这些化合物的合成和 SAR，以及 X 射线晶体学、抗增殖和选择性数据。 (C) 2012 年，爱思唯尔有限公司出版。
Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data. (C) 2012 Published by Elsevier Ltd.