Lessons from viral manipulation of protein disposal pathways
Lessons from viral manipulation of protein disposal pathways
复制标题
DOI：
10.1172/jci200216831
复制
发表时间：
2002-10-01
影响因子：
15.9
通讯作者：
Ploegh, HL
中科院分区：
文献类型：
--
作者：
Furman, MH;Ploegh, HL
MHC I类复合物的合成和组装。MHC I类重链互补插入ER中。正确折叠、与β2m轻链的结合和肽装载由分子伴侣如钙连接蛋白、钙网蛋白、tapasin和ERp57辅助。E1、E2和E3泛素结合酶标记胞质溶胶中的蛋白质，以被蛋白酶体破坏。肽通过TAP转运蛋白泵入ER。正确折叠的肽负载的MHC I类复合物通过分泌途径在细胞表面上展示。TAP，抗原加工相关转运蛋白。
MHC class I complex synthesis and assembly. MHC class I heavy chains are cotranslationally inserted into the ER. Proper folding, association with the β2m light chain, and peptide loading are assisted by chaperones such as calnexin, calreticulin, tapasin, and ERp57. E1, E2, and E3 ubiquitin-conjugating enzymes tag proteins in the cytosol for destruction by the proteasome. Peptides are pumped into the ER by the TAP transporters. Properly folded, peptide-loaded MHC class I complexes progress through the secretory pathway for display on the cell surface. TAP, transporter associated with antigen processing.