Serum bilirubin and 10-year mortality risk in a Belgian population
Serum bilirubin and 10-year mortality risk in a Belgian population
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DOI：
10.1023/a:1013794407325
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发表时间：
2001-12-01
影响因子：
2.3
通讯作者：
Kesteloot, H
中科院分区：
文献类型：
--
作者：
Temme, EHM;Zhang, JJ;Kesteloot, H
目的：内源性抗氧化剂血清胆红素可以清除自由基，预防自由基相关疾病。方法：利用比利时大学间营养与健康研究 (BIRNH) 的 10 年随访死亡率数据，对 5460 名男性和 4843 名女性的血清胆红素与全因、心血管和癌症死亡率之间的关系进行了调查。结果：在男性中，最高（大于或等于与最低血清胆红素浓度（低于或等于 0.2 mg/dl）相比，调整后的全因相对风险 (RR) 为 0.73（95% 置信区间 (CI) 0.57-0.94），癌症死亡率为 0.42（95% CI 0.26-0.68）。癌症死亡风险随着血清胆红素浓度的增加而降低（趋势 p = 0.004），尤其是非肺癌死亡率（趋势 p = 0.02）。在对吸烟进行调整后，这种关联仍然存在。在女性中，血清胆红素与癌症死亡率之间的相关性相同，但未达到统计学显着性（RR=0.76，95% CI 0.39-1.5）。在男性和女性中，血清胆红素与心血管死亡率之间没有发现显着关联。结论：然而，在该人群中，在正常范围内的高血清胆红素与低癌症死亡率相关，尤其是在男性中。这可能是由于胆红素的抗氧化活性。血清胆红素浓度的测量可能有助于癌症风险评估。
Objective: The endogenous antioxidant serum bilirubin may scavenge free radicals and protect against free radical-related diseases.Methods: Using the 10-year follow-up mortality data from the Belgium Inter-university Research on Nutrition and Health (BIRNH) study the association between serum bilirubin and all-cause, cardiovascular, and cancer mortality in 5460 men and 4843 women was investigated.Results: In men, with the highest (greater than or equal to0.6 mg/dl) compared with the lowest serum bilirubin concentration (less than or equal to0.2 mg/dl), the adjusted relative risk (RR) was 0.73 (95% confidence interval (CI) 0.57-0.94) for all-cause and 0.42 (95% CI 0.26-0.68) for cancer mortality. The risk for cancer mortality decreased with increasing concentrations of serum bilirubin (p for trend = 0.004) especially for non-lung cancer mortality (p for trend = 0.02). The associations persisted after adjusting for smoking. In women the associations between serum bilirubin and cancer mortality were in the same direction, but did not reach statistical significance (RR=0.76, 95% CI 0.39-1.5). No significant associations were found between serum bilirubin and cardiovascular mortality in men and women.Conclusions: In this population high serum bilirubin, however, within normal ranges, was associated with low cancer mortality, especially in men. This may be due to the antioxidant activity of bilirubin. Measurement of serum bilirubin concentrations may contribute to cancer risk estimation.