Crossing paths in Human Renal Cell Carcinoma (hRCC).
Crossing paths in Human Renal Cell Carcinoma (hRCC).
复制标题
人肾细胞癌（HRCC）中的跨越路径。
DOI：
10.3390/ijms131012710
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发表时间：
2012-10-05
影响因子：
5.6
通讯作者：
Aparicio LM
中科院分区：
文献类型：
--
作者：
Gallego GA;Villaamil VM;Grande E;Caínzos IS;Aparicio LM
从历史上看，细胞信号传导途径已被研究为将孤立的元件编译成将细胞外刺激传递到肿瘤细胞核的独特级联。如今，越来越多的证据支持这样一个事实，即肿瘤进展的细胞内驱动因素并不以单一的线性途径流动，而是扩散到多个细胞内途径中。对癌症复杂性的进一步理解取决于在细胞和细胞间水平及其时间维度上阐明潜在的调控网络。细胞内级联的高度复杂性导致完全抑制一个肿瘤细胞的生长是非常不可能的，除非在所谓的“癌基因成瘾”已知是肿瘤灾难的明确触发因素的情况下，例如在胃肠道间质瘤或慢性髓性白血病的情况下。换句话说，需要将驾驶员与乘客分开和隔离，以提高癌症治疗的准确性。这篇综述将总结控制肾细胞癌增殖的信号通路十字路口，以及对这些通路如何促进肿瘤逃逸的新认识。我们概述了现有的证据支持不同的信号通路之间的联系，以及它们如何影响肿瘤的增殖，分化，凋亡，血管生成，代谢和侵袭性。结论是肿瘤细胞可能在信号通路之间产生自己的十字路口/串扰，从而减少它们对生理通路刺激的依赖。
Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence supports the fact that intracellular drivers of tumor progression do not flow in a single linear pathway, but disseminate into multiple intracellular pathways. An improved understanding of the complexity of cancer depends on the elucidation of the underlying regulatory networks at the cellular and intercellular levels and in their temporal dimension. The high complexity of the intracellular cascades causes the complete inhibition of the growth of one tumor cell to be very unlikely, except in cases in which the so-called “oncogene addiction” is known to be a clear trigger for tumor catastrophe, such as in the case of gastrointestinal stromal tumors or chronic myeloid leukemia. In other words, the separation and isolation of the driver from the passengers is required to improve accuracy in cancer treatment. This review will summarize the signaling pathway crossroads that govern renal cell carcinoma proliferation and the emerging understanding of how these pathways facilitate tumor escape. We outline the available evidence supporting the putative links between different signaling pathways and how they may influence tumor proliferation, differentiation, apoptosis, angiogenesis, metabolism and invasiveness. The conclusion is that tumor cells may generate their own crossroads/crosstalk among signaling pathways, thereby reducing their dependence on stimulation of their physiologic pathways.
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影响因子：
64.8
作者：
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通讯作者：
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