Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation
Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation
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DOI：
10.1364/ol.34.001525
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发表时间：
2009-05-15
期刊：
影响因子：
3.6
通讯作者：
Sterenborg, Henricus J. C. M.
中科院分区：
文献类型：
--
作者：
Amelink, Arjen;Christiaanse, Theo;Sterenborg, Henricus J. C. M.
对含有红细胞的散射体模进行光纤反射率测量。通过氮气鼓泡降低模型中的氧气压力，同时仔细控制和监测温度（37 摄氏度）和 pH 值（7.4）。通过将 350-850 nm 波长范围内的光谱拟合到包含颜料包装影响的模型，从光学光谱测量中提取血氧饱和度 (SO2)。分析了使用不同氧合和脱氧血红蛋白消光光谱对拟合质量和准确性的影响。将光学提取的 SO2 与标准氧解离曲线 (ODC) 进行比较。根据血红蛋白消光光谱的选择，ODC 和光学提取的 SO2 之间的绝对偏差在测量的饱和度范围 (4%-99%) 上小于 2.5%。 (C) 2009 美国光学学会
Fiber-optic reflectance measurements were performed on scattering phantoms containing red blood cells. The oxygen pressure in the phantom was decreased by nitrogen gas bubbling, while carefully controlling and monitoring the temperature (37 degrees C) and pH (7.4). The blood oxygen saturation (SO2) was extracted from the optical spectroscopic measurements by fitting the spectra over the wavelength range of 350-850 nm to a model that includes the effects of pigment packaging, The effect of using different oxy- and deoxyhemoglobin extinction spectra on the quality and accuracy of the fits is analyzed. The optically extracted SO2 is Compared with the standard oxygen dissociation Curve (ODC). Depending on the choice of hemoglobin extinction spectra the absolute deviation between the ODC and the optically extracted SO2 is less than 2.5% over the measured range of saturations (4%-99%). (C) 2009 Optical Society of America