Bone mineral content in early-postmenopausal and postmenopausal osteoporotic women: comparison of measurement methods.
Bone mineral content in early-postmenopausal and postmenopausal osteoporotic women: comparison of measurement methods.
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绝经后早期和绝经后骨质疏松女性的骨矿物质含量：测量方法的比较。
DOI：
10.1148/radiology.160.2.3726129
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发表时间：
1986
期刊：
影响因子：
19.7
通讯作者：
Ettinger,B
中科院分区：
文献类型：
--
作者：
Reinbold,WD;Genant,HK;Reiser,UJ;Harris,ST;Ettinger,B
为了研究非侵入性骨量测量方法之间的相关性，我们研究了40名健康的绝经后早期妇女和68名患有骨质疏松症的老年妇女。方法包括腰椎的单、双能量定量CT(QCT)和双光子吸收法(DPA)，桡骨远端1/3的单光子吸收法(SPA)和第二掌骨干的联合皮质厚度(CCT)。行胸腰椎侧位X线片，计算脊柱骨折指数。在绝经早期妇女中，QCT和DPA方法具有良好的相关性，而在绝经后骨质疏松妇女中相关性较弱。在健康女性中，脊柱测量(QCT或DPA)和附件皮质测量(SPA或CCT)之间的相关性不大，而在骨质疏松女性中相关性较差。一种方法的测量结果不能预测另一种方法对单个患者的测量结果。与脊柱骨折严重程度的相关性最强的是QCT，最弱的是SPA。单能量和双能量QCT结果之间有很高的相关性，表明在这些绝经后女性中，椎体脂肪引起的误差并不显著。单能量QCT对绝经后妇女的评估可能是足够的，也许是更可取的。QCT测量腰椎松质骨密度可区分骨质疏松妇女和年轻健康妇女，较DPA测量脊柱整体骨或SPA或CCT测量附件皮质骨更敏感。
To investigate associations among methods for noninvasive measurement of skeletal bone mass, we studied 40 healthy early postmenopausal women and 68 older postmenopausal women with osteoporosis. Methods included single- and dual-energy quantitative computed tomography (QCT) and dual-photon absorptiometry (DPA) of the lumbar spine, single-photon absorptiometry (SPA) of the distal third of the radius, and combined cortical thickness (CCT) of the second metacarpal shaft. Lateral thoracolumbar radiography was performed, and a spinal fracture index was calculated. There was good correlation between QCT and DPA methods in early postmenopausal women and modest correlation in postmenopausal osteoporotic women. Correlations between spinal measurements (QCT or DPA) and appendicular cortical measurements (SPA or CCT) were modest in healthy women and poor in osteoporotic women. Measurements resulting from one method are not predictive of those by another method for the individual patient. The strongest correlation with severity of vertebral fracture is provided by QCT; the weakest, by SPA. There was a high correlation between single- and dual-energy QCT results, indicating that errors due to vertebral fat are not substantial in these postmenopausal women. Single-energy QCT may be adequate and perhaps preferable for assessing postmenopausal women. The measurement of spinal trabecular bone density by QCT discriminates between osteoporotic women and younger healthy women with more sensitivity than measurements of spinal integral bone by DPA or of appendicular cortical bone by SPA or CCT.