Dopamine: an immune transmitter.
Dopamine: an immune transmitter.
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DOI：
10.4103/1673-5374.284976
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发表时间：
2020-12
影响因子：
6.1
通讯作者：
Castorina A
中科院分区：
文献类型：
--
作者：
Thomas Broome S;Louangaphay K;Keay KA;Leggio GM;Musumeci G;Castorina A
多巴胺能系统控制着几个重要的中枢神经系统功能，包括控制运动、奖励行为和认知。多巴胺能信号的改变参与神经退行性和精神疾病的发病机制，特别是帕金森病，这与微妙的慢性炎症反应有关。大量证据表明，多巴胺及其受体和控制多巴胺合成、分泌和储存的机制在几种免疫细胞类型中具有非神经元性表达。本文综述了多巴胺在免疫细胞中的作用和表达。目标之一是破译这些细胞类型对多巴胺作出反应的复杂机制，以解决多巴胺对神经退行性疾病和帕金森病等精神疾病的影响。进一步的目的是阐明我们对多巴胺生理作用的理解差距，以鼓励更有针对性的研究，重点了解异常多巴胺产生对免疫调节的影响。这些亮点可能促使该领域的科学家在针对神经炎症/神经退行性病变时考虑这种重要神经递质的替代功能。
The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies.