FORMATION OF POLYMER VESICLES FROM MICRODROPLETS OF POLYION COMPLEX AND EXAMINATION OF THEIR PHYSICOCHEMICAL PROPERTIES IN MICROFLUIDIC CHAMBER
FORMATION OF POLYMER VESICLES FROM MICRODROPLETS OF POLYION COMPLEX AND EXAMINATION OF THEIR PHYSICOCHEMICAL PROPERTIES IN MICROFLUIDIC CHAMBER
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发表时间：
2011-12
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通讯作者：
H. Oana;M. Morinaga;A. Kishimura;M. Gel;K. Kataoka;M. Washizu
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作者：
H. Oana;M. Morinaga;A. Kishimura;M. Gel;K. Kataoka;M. Washizu
本文直接观察了单个巨型聚合物囊泡的非平凡形成过程，即多离子复合物（PIC）微滴直接形成囊泡，并确定了PIC囊泡形成的最佳条件，为高效量产提供了基础。此外，来宾聚合物的封装及其在PIC囊泡内的保留，以及通过组成聚合物的交联修饰PIC膜的性能。所有实验都是在微流控室中完成的，该微流控室可以控制溶液条件，并将目标物体保持在光学显微镜的视野范围内。
This paper presents a direct observation of a non-trivial formation process of individual giant polymer vesicles, i.e., direct formation of vesicles from microdroplets of polyion complex (PIC) and the optimum condition for the formation of the PIC vesicles, providing a basis for an efficient mass-production. In addition, encapsulation of guest polymers and their retention within the PIC vesicle are demonstrated as well as modification of property of the PIC membrane by crosslinking of the constituent polymers. All experiments were achieved in a microfluidic chamber which can control solution conditions with keeping targeted objects under the view field of the optical microscope.