Prompt gamma ray diagnostics and enhanced hadron-therapy using neutron-free nuclear reactions
Prompt gamma ray diagnostics and enhanced hadron-therapy using neutron-free nuclear reactions
复制标题
利用无中子核反应进行即时伽马射线诊断和增强强子治疗
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
G. Korn
中科院分区：
文献类型：
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作者：
L. Giuffrida;D. Margarone;G. Cirrone;A. Picciotto;G. Cuttone;G. Korn
我们提出了一系列的模拟硼同位素的潜在用途，通过与入射的高能质子束的相互作用，在癌细胞中触发无中子（非中子）的核反应，从而导致在发射的特征提示γ辐射（429千电子伏，718千电子伏和1435千电子伏）。此外，假设硼同位素在癌细胞中被吸收，在每个p-11B非中子核聚变反应中产生的三个α粒子可能导致肿瘤区域中吸收的生物剂量的增加，因为这些多MeV α粒子被阻止在单个癌细胞内，从而使周围组织得以保留。尽管在[Yoon et al. Applied Physics Letters 105，223507（2014）]中提出了一种基于使用11B核的类似方法，但我们的工作使用Monte Carlo模拟证明了使用10 B核（在也包含11B的溶液中）对于产生瞬发伽马射线的至关重要性，该伽马射线可以产生...
We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the emission of characteristic prompt gamma radiation (429 keV, 718 keV and 1435 keV). Furthermore assuming that the Boron isotopes are absorbed in cancer cells, the three alpha-particles produced in each p-11B aneutronic nuclear fusion reactions can potentially result in the enhancement of the biological dose absorbed in the tumor region since these multi-MeV alpha-particles are stopped inside the single cancer cell, thus allowing to spare the surrounding tissues. Although a similar approach based on the use of 11B nuclei has been proposed in [Yoon et al. Applied Physics Letters 105, 223507 (2014)], our work demonstrate, using Monte Carlo simulations, the crucial importance of the use of 10B nuclei (in a solution containing also 11B) for the generation of prompt gamma-rays, whic...