Dynamic repositioning of CD4 and CD8 genes during T cell development
Dynamic repositioning of CD4 and CD8 genes during T cell development
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DOI：
10.1084/jem.20041041
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发表时间：
2004-12-06
影响因子：
15.3
通讯作者：
Robey, EA
中科院分区：
文献类型：
--
作者：
Delaire, S;Huang, YH;Robey, EA
尽管 CD4 和 CD8 基因的稳定抑制是 T 细胞谱系定型的核心特征，但我们缺乏有关这种抑制的时间和机制的详细信息。稳定的基因抑制与基因在细胞核内的位置有关。因此，有关 T 细胞发育过程中 CD4 和 CD8 基因核位置的信息可以深入了解 CD4 和 CD8 基因的调节机制以及谱系定型过程。在这里，我们报告 CD4 和 CD8 基因的谱系特异性抑制与靠近异染色质的等位基因的重新定位有关。我们还提供证据表明，CD4 和 CD8 基因重新定位到异染色质可能是对正选择信号的早期反应。我们根据目前对 CD4 和 CD8 基因调控以及 CD4 与 CD8 谱系承诺的了解来讨论我们的结果。
Although stable repression of CD4 and CD8 genes is a central feature of T cell lineage commitment, we lack detailed information about the timing and mechanism of this repression. Stable gene repression has been linked to the position of genes within the nucleus. Therefore, information about the nuclear position of CD4 and CD8 genes during T cell development could provide insights into both the mechanism of regulation of CD4 and CD8 genes, and the process of lineage commitment. Here, we report that lineage-specific repression of CD4 and CD8 genes is associated with the repositioning of alleles close to heterochromatin. We also provide evidence that the relocalization of CD4 and CD8 genes to heterochromatin can occur as an early response to positive selection signals. We discuss our results in terms of our current knowledge of CD4 and CD8 gene regulation and CD4 versus CD8 lineage commitment.