Glutathione S-transferase polymorphisms may be associated with risk of oedematous severe childhood malnutrition
Glutathione S-transferase polymorphisms may be associated with risk of oedematous severe childhood malnutrition
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谷胱甘肽 S-转移酶多态性可能与水肿性严重儿童营养不良的风险相关
DOI：
10.1079/bjn20061825
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发表时间：
2006
影响因子：
3.6
通讯作者：
C. McKenzie
中科院分区：
文献类型：
--
作者：
K. Marshall;S. Howell;M. Reid;A. Badaloo;M. Farrall;T. Forrester;C. McKenzie
据估计，超过 50% 的 5 岁以下死亡病例的根本原因是营养不良。严重儿童营养不良是营养不良的一种极端形式，以水肿和非水肿综合征的形式出现。为什么只有部分儿童出现水肿性严重儿童营养不良 (OSCM) 的原因仍然难以捉摸，但来自相对同质背景的儿童临床表现的异质性表明，对 OSCM 的易感性可能存在个体差异。我们在一项回顾性研究中研究了四种谷胱甘肽 S-转移酶 (GST) 基因的变异体，对象是之前入住牙买加热带代谢研究中心的受试者 (n136)，用于治疗 OSCM（病例）或非水肿性严重儿童营养不良（对照）。我们发现 GSTP1 Val105 纯合子在病例中更为常见（比值比 (OR) 3·5；95% CI 1·1、10·8）。我们还发现非缺失 GSTT1 基因型（即 +/+ 或 +/0）与 OSCM 之间存在临界显着性关联（OR 2·4；95% CI 1·0、5·9）。 OSCM 与任何其他 GST 变体之间没有显着关联。这些初步研究结果表明，GST 超家族内的遗传变异可能会增加 OSCM 的风险。为了正确评估遗传变异对 OSCM 风险的真正贡献（如果有），需要额外的、更大的数据集和对其他候选基因变异的研究。此类研究可能会提高我们对营养不良临床异质性原因的理解。
It has been estimated that more than 50% of deaths before the age of 5 years have undernutrition as an underlying cause. Severe childhood malnutrition, an extreme form of undernutrition, occurs as oedematous and non-oedematous syndromes. The reasons why only some children develop oedematous severe childhood malnutrition (OSCM) have remained elusive, but the heterogeneity of clinical appearances among children from relatively homogeneous backgrounds suggests that interindividual variation in susceptibility to OSCM may exist. We investigated variants of four glutathione S-transferase (GST) genes in a retrospective study among subjects (n136) previously admitted to the Tropical Metabolism Research Unit, Jamaica, for the treatment of either OSCM (cases) or non-oedematous severe childhood malnutrition (controls). We found that GSTP1 Val105 homozygotes were significantly more common among the cases (odds ratio (OR) 3·5; 95% CI 1·1, 10·8). We also found an association of borderline significance between non-deletion GSTT1 genotypes (i.e. +/+ or +/0) and OSCM (OR 2·4; 95% CI 1·0, 5·9). There was no significant association between OSCM and any of the other GST variants. These preliminary findings suggest that genetic variation within the GST superfamily may contribute to the risk of OSCM. Additional, larger data sets and studies of variants in other candidate genes are required in order to properly assess the true contribution, if any, of genetic variation to risk of OSCM. Such studies may improve our understanding of the causes of clinical heterogeneity in malnutrition.
影响因子：
12.7
作者：
Cooper, R;Rotimi, C;Wilks, R
通讯作者：
Wilks, R
DOI：
10.1111/j.1432-1033.1994.00893.x
发表时间：
1994-09-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
ZIMNIAK, P;NANDURI, B;AWASTHI, YC
通讯作者：
AWASTHI, YC