Gut microbiota composition is associated with temperament traits in infants
Gut microbiota composition is associated with temperament traits in infants
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DOI：
10.1016/j.bbi.2019.05.035
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发表时间：
2019-08-01
影响因子：
15.1
通讯作者：
Karlsson, Linnea
中科院分区：
文献类型：
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作者：
Aatsinki, Anna-Katariina;Lahti, Leo;Karlsson, Linnea
背景资料：婴儿期的关键行为表型之一是不同的气质特征，某些早期生活气质特征已被证明是后来心理健康问题的先兆。肠道微生物群组成（GMC）的差异被认为与神经发育有关。例如，已经发现幼儿气质特征与GMC的差异有关;然而，尽管婴儿期是神经发育和GM发育的快速时期，但缺乏对婴儿的研究。因此，我们的目的是调查婴儿GMC和气质之间的关联。方法：研究人群（n = 301，53%为男孩）来自FinnBrain出生队列研究。从2.5个月大的婴儿中收集粪便样本，并使用16 S Illumina MiSeq平台进行测序。GMC分类组成（在属和OTU水平），观察到的样本集群，多样性和丰富性进行了研究，在6个月的婴儿行为量表修订版（IBQ-R）的母亲报告。结果如下：基于GMC，共鉴定出3个样本类群（双歧杆菌/肠杆菌科、拟杆菌属和异杆菌属），其中双歧杆菌/肠杆菌科类群在IBQ-R主维度调节和子量表定向持续时间上的得分均高于拟杆菌属类群。与气质相关的集群以性别依赖的方式。IBQ-R主维度激越（积极情绪性）与双歧杆菌属和链球菌属均呈正相关。α多样性与消极情绪和恐惧反应呈负相关。结论：这是第一个研究表明协会，但不是因果关系，GMC和气质之间的幼儿在一个前瞻性的设计。
Background: One of the key behavioral phenotypes in infancy are different temperament traits, and certain early life temperament traits have been shown to precede later mental health problems. Differences in the gut microbiota composition (GMC) have been suggested to link with neurodevelopment. For example, toddler temperament traits have been found to associate with differences in GMC; however, studies in infants are lacking although infancy is a rapid period of neurodevelopment as well as GM development. Thus, we aimed to investigate association between infant GMC and temperament. Methods: The study population (n = 301, 53% boys) was drawn from the FinnBrain Birth Cohort Study. Stool samples were collected from the 2.5-month-old infants and sequenced with 16S Illumina MiSeq platform. GMC taxonomic composition (at Genus and OTU level), observed sample clusters, diversity and richness were investigated in relation to the maternal reports of Infant Behavior Questionnaire-Revised (IBQ-R) at the age of 6 months. Results: Three sample clusters (Bifidobacterium/Enterobacteriaceae, Bacteroides, V. Dispar) based on GMC were identified, of which Bifidobacterium/ Enterobacteriaceae cluster presented with higher scores on the IBQ-R main dimension regulation and its subscale duration of orienting compared to Bacteroidescluster. The clusters associated with temperament in a sex-dependent manner. The IBQ-R main dimension surgency (positive emotionality) was associated positively both with genus Bifidobacterium and Streptococcus. Alpha diversity had a negative association with negative emotionality and fear reactivity. Conclusion: This is the first study demonstrating associations, but not causal connections, between GMC and temperament in young infants in a prospective design.