Erythrina studies part 37 -: Cytotoxic isoflavones from Erythrina indica
Erythrina studies part 37 -: Cytotoxic isoflavones from Erythrina indica
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DOI：
10.1016/s0031-9422(01)00368-5
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发表时间：
2001-12-01
期刊：
影响因子：
3.8
通讯作者：
van Heerden, FR
中科院分区：
文献类型：
--
作者：
Nkengfack, AE;Azebaze, AGB;van Heerden, FR
对 Erythrina indica 茎皮的 CH2Cl2-MeOH (1:1) 提取物进行生物测定指导分馏，分离出两种现在称为 indicanines D 和 E 的异黄酮衍生物以及 11 种已知化合物，包括：六种异黄酮（染料木黄酮、wighteone、alpinumisoflavone、二甲基alpinumisoflavone。8-异戊二烯基赤蓟素 C 和erysenegalensein E）、一种肉桂酸酯（erythrinassinate B）、两种五环三萜（齐墩果酸和高根二醇）和两种植物甾醇（豆甾醇及其 3-O-β-D-吡喃葡萄糖苷）。通过光谱分析阐明了新化合物的结构。还报道了一些分离的化合物对 KB 细胞的体外杀细胞活性。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Bioassay-directed fractionation of the CH2Cl2-MeOH (1:1) extract of the stem bark of Erythrina indica, has resulted in the isolation of two now isoflavone derivatives named indicanines D and E together with 11 known compounds including: six isoflavones (genistein, wighteone, alpinumisoflavone, dimethylalpinumisoflavone. 8-prenyl erythrinin C, and erysenegalensein E), one cinnamate (erythrinassinate B), two pentacyclic triterpenes (oleanolic acid and erythrodiol), and two phytosterols (stigmasterol and its 3-O-beta -D-glucopyranoside). The structures of the new compounds were elucidated by means of spectroscopic analysis. The in vitro cytocidal activity against KB cells of some of the isolated compounds is also reported. (C) 2001 Elsevier Science Ltd. All rights reserved.