Greater oxidative stress in healthy young men compared with premenopausal women
Greater oxidative stress in healthy young men compared with premenopausal women
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DOI：
10.1161/hq0302.104515
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发表时间：
2002-03-01
影响因子：
8.7
通讯作者：
Takeshita, A
中科院分区：
文献类型：
--
作者：
Ide, T;Tsutsui, H;Takeshita, A
冠状动脉危险因素，包括年龄、高血压、糖尿病、高脂血症和吸烟，与增强的氧化应激相关，其被认为是动脉粥样硬化形成和动脉粥样硬化性心血管疾病的潜在机制。男性是众所周知的心血管危险因素之一。我们测试了假设，氧化应激是男性比女性更大。在52名年轻男性和51名年龄匹配的女性中测定了血浆硫代巴比妥酸反应物质（TBARS）和尿8-异前列腺素F-2 α（8-iso-PGF 2 α）。受试者健康，不吸烟，未服用任何药物或维生素。年龄、血压、血浆胆固醇和血糖在两组之间没有差异。基线TBARS（2.32 +/- 0.11 [男性] vs 1.87+/-0.09 [女性] mmol/mL，P
Coronary risk factors, including age, hypertension, diabetes mellitus, hyperlipidemia, and smoking, are associated with enhanced oxidative stress, which is implicated as a potential mechanism for atherogenesis and atherosclerotic cardiovascular diseases. Male sex is one of the well-known cardiovascular risk factors. We tested the hypothesis that oxidative stress is greater in men than in women. Plasma thiobarbituric acid-reactive substances (TBARS) and urinary 8-isoprostaglandin F-2alpha (8-iso-PGF2alpha) were measured in 52 young men and 51 age-matched women. The subjects were healthy, were not smokers, and were not taking any medications or vitamins. Age, blood pressure, plasma cholesterol, and glucose did not differ between the groups. Baseline TBARS (2.32 +/- 0.11 [men] versus 1.87+/-0.09 [women] mnol/mL, P