Tris(azidoethyl)amine Hydrochloride; a Versatile Reagent for Synthesis of Functionalized Dumbbell Oligodeoxynucleotides
Tris(azidoethyl)amine Hydrochloride; a Versatile Reagent for Synthesis of Functionalized Dumbbell Oligodeoxynucleotides
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DOI：
10.1021/ol400001w
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发表时间：
2013-02-01
期刊：
影响因子：
5.2
通讯作者：
Matsuda, Akira
中科院分区：
文献类型：
--
作者：
Ichikawa, Satoshi;Ueno, Hideaki;Matsuda, Akira
采用Cu（I）催化的烯丙炔-叠氮环加成反应，与三叠氮乙基胺盐酸盐和3 '端和5'端均含N-3-炔丙基胸苷的寡脱氧核苷酸反应，合成了三唑交联的寡脱氧核苷酸。通过利用剩余的叠氮基，实现了功能分子到哑铃形寡脱氧核苷酸的进一步安装。
Triazole-cross-linked oligodeoxynucleotides were synthesized using the Cu(I) catalyzed allryne-azide cycloaddition with tris(azidoethyl)amine hydrochloride and oligodeoxynucleotides possessing N-3-(propargyl)thymidine at both the 3'- and 5'-terminl. Further installation of a functional molecule to the dumbbell oligodeoxynucleotides was achieved by utilizing the remaining azide group.