Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study
Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study
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DOI：
10.1183/09031936.04.00127603
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发表时间：
2004-12-01
影响因子：
24.3
通讯作者：
Papadimitriou, A
中科院分区：
文献类型：
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作者：
Alchanatis, M;Deligiorgis, N;Papadimitriou, A
阻塞性睡眠呼吸暂停综合征患者常存在认知缺陷，尤其是与执行功能相关的认知缺陷，不能完全用白天嗜睡来解释，经鼻持续气道正压治疗后部分不可逆。这些认知缺陷的因果机制尚不清楚，但有人提出它们与化学和结构性脑细胞损伤有关。本研究的目的是研究睡眠呼吸暂停综合征患者的脑代谢。采用单体素质子磁共振波谱技术对22例重度睡眠呼吸暂停患者和10名年龄相仿的健康志愿者进行了研究。获得前额叶皮层、顶枕叶和额叶脑室周围白质的磁共振波谱。与对照组相比，阻塞性睡眠呼吸暂停患者额叶白质中n -乙酰天冬氨酸与肌酸和胆碱与肌酸的比值显著降低。睡眠呼吸暂停患者额叶白质中n -乙酰天冬氨酸和胆碱的绝对浓度也显著降低。额叶白质病变已知与认知执行功能障碍有关。这项研究的发现可能为与睡眠呼吸暂停有关的有时不可逆转的认知缺陷提供了解释。
Patients with obstructive sleep apnoea syndrome frequently have cognitive deficits, especially related to executive functions, which cannot be fully explained by daytime sleepiness and are partial irreversible after nasal continuous positive airway pressure treatment. The causal mechanism of these cognitive deficits is not yet known, but it has been proposed that they are associated with chemical and structural brain cell injury. The aim of this study was to investigate brain metabolism in patients with sleep apnoea syndrome.Twenty-two patients with severe sleep apnoea and 10 healthy volunteers of comparable age were studied using single voxel proton magnetic resonance spectroscopy. Magnetic resonance spectra were obtained from prefrontal cortex, parieto-occipital and frontal periventricular white matter. N-acetylaspartate-to-creatine and choline-to-creatine ratios were significantly lower in the frontal white matter of obstructive sleep apnoea patients when compared to controls. Absolute concentrations of N-acetylaspartate and choline were also significantly reduced in the frontal white matter of patients with sleep apnoea.Frontal lobe white matter lesions are known to be associated with cognitive executive dysfunction. The findings of this study may offer an explanation for the sometimes irreversible cognitive deficits associated with sleep apnoea.