Comparison of Cardiovascular Parameters Between Patients With Ossification of Posterior Longitudinal Ligament and Patients With Cervical Spondylotic Myelopathy
Comparison of Cardiovascular Parameters Between Patients With Ossification of Posterior Longitudinal Ligament and Patients With Cervical Spondylotic Myelopathy
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后纵韧带骨化症患者与脊髓型颈椎病患者心血管参数比较
DOI：
10.1097/bsd.0b013e31817eee55
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发表时间：
2009
影响因子：
--
通讯作者：
S. Toh
中科院分区：
文献类型：
--
作者：
M. Kishiya;K. Furukawa;T. Yokoyama;H. Kudo;A. Ono;Takuya Numasawa;Kanichiro Wada;S. Toh
背景资料总结后纵韧带骨化（OPLL）是脊柱韧带组织中的异位骨形成，由于脊髓和神经根的慢性压力导致脊髓病。将其进一步分为4种类型，即分段型、连续型、混合型和其他类型；然而，这些类型之间骨化进展的细节差异和疾病的自然史尚未明确。目的探讨与OPLL疾病状态相关的全身特征。方法对OPLL、脊髓型颈椎病（CSM）和OPLL亚型（连续型、混合型、节段型和其他类型）的心血管因素[血压、术中或术后失血量、出血时间、凝血因子（凝血酶原试验、活化部分凝血活酶时间）]进行了研究。研究设计回顾性病例系列。结果以脊髓型颈椎病患者为对照（CSM患者）。虽然出血时间、凝血因子差异无统计学意义，但OPLL患者术后出血量明显高于CSM患者（P<0.01）。连续型骨化患者的失血量显著高于节段型骨化患者（P<0.05），与CSM患者的失血量几乎相等。混合型骨化患者的失血量表现为节段型和连续型的中间值。
Summary of Background Data Ossification of the posterior longitudinal ligament (OPLL) is an ectopic bone formation in the ligament tissue of the spine, causing myelopathy as a result of chronic pressure on the spinal cord and nerve roots. It has been further categorized into 4 types, that is, segmental, continuous, mixed types, and the other types; however, differences in the detail of the progression in the ossification and natural history of the disease among these types have not been clarified. Objective To find out the systemic feature, which has relevance to the disease state of OPLL. Methods To characterize these types, we conducted an investigation of cardiovascular factors [blood pressure, blood loss during or after surgery, bleeding time, coagulation factors (prothrombin test, activated partial thromboplastin time)] among OPLL, cervical spondylotic myelopathy (CSM), and subtypes of OPLL (continuous, mixed, segmental, and the other types). Study Design Retrospective case series. Results These parameters of patients with cervical spondylotic myelopathy were used as a control (CSM patients). Although there was no significant difference in bleeding time and coagulation factors, blood loss after surgery of OPLL patients was significantly higher than that of CSM patients (P<0.01). Furthermore, blood loss of patients with continuous type of ossification was significantly higher (P<0.05) than that of patients with segmental type of ossification, which was nearly equal to that of CSM patients. Blood loss of patients with mixed type of ossification showed the value of the middle of segmental and continuous types.
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影响因子：
4.2
作者：
Iwasaki, K;Furukawa, KI;Motomura, S
通讯作者：
Motomura, S
影响因子：
3
作者：
Tahara, M;Aiba, A;Okawa, A
通讯作者：
Okawa, A
影响因子：
2.5
作者：
Li, MQ;Amizuka, N;Maeda, T
通讯作者：
Maeda, T
DOI：
--
发表时间：
2006
期刊：
Journal of Pharmacological Science 100
影响因子：
--
作者：
Yamaya M.;Shibahara S.;Ken-Ichi Furukawa
通讯作者：
Ken-Ichi Furukawa
基因表达分析鉴定的 PLZF 和 TSG-6 在 OPLL 的发病机制中发挥作用
DOI：
--
发表时间：
2006
期刊：
Journal of Pharmacological Science 100
影响因子：
--
作者：
Yamaya M.;Shibahara S.;Ken-Ichi Furukawa;Ken-Ichi Furukawa;Ituro Inoue
通讯作者：
Ituro Inoue