Dexamethasone-induced changes in lung function are not prevented by concomitant treatment with retinoic acid.
Dexamethasone-induced changes in lung function are not prevented by concomitant treatment with retinoic acid.
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与视黄酸同时治疗并不能阻止地塞米松引起的肺功能变化。
DOI：
10.1152/ajplung.00423.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Bruce,MargaretC
中科院分区：
文献类型：
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作者：
Srinivasan,Ganesh;Bruce,EugeneN;Houtz,PamelaK;Bruce,MargaretC
在出生后4-13天用地塞米松（Dex）处理的大鼠中肺泡化受损，但是用全反式维甲酸（RA）伴随处理增加肺泡数量。为了确定Dex和/或RA诱导的形态学变化是否可预测1个月时肺功能的变化，我们评估了静息呼吸参数、动态顺应性、维持氧饱和度≥ 90%所需的通气量以及充满空气的肺的压力-容积曲线。静息呼吸时，Dex + RA组大鼠每克潮气量显著高于对照组（P< 0.05）。Dex组和Dex + RA组大鼠的动态顺应性也明显高于对照组和RA组（P< 0.02）。在Dex和Dex + RA治疗的大鼠中，我们观察到滞后比（P≤ 0.006）、空气滞留（P< 0.05）和5和13.5 cmH 2 O压力下的肺体积（P< 0.001）增加，弹性回缩减少（P< 0.007）。Dex对弹性回缩的影响雌性大鼠大于雄性大鼠（P= 0.006）。尽管受损的分隔，O2饱和度没有受到损害的地塞米松或地塞米松+RA治疗的大鼠。因此，在肺泡化过程中Dex治疗诱导的肺功能变化不能通过与RA合并治疗来预防。
Alveolarization is impaired in rats treated with dexamethasone (Dex) on postnataldays 4–13, but concomitant treatment with all-transretinoic acid (RA) increases alveolar number. To determine whether morphological changes induced by Dex and/or RA predict changes in lung function at 1 mo, we assessed resting breathing parameters, dynamic compliance, ventilation required to maintain O2saturation at ≥90%, and pressure-volume curves of air-filled lungs. During resting breathing, mean tidal volume per gram was greater in Dex + RA-treated rats than in controls (P< 0.05). Dynamic compliance was also greater in Dex- and Dex + RA-treated rats than in controls or RA-treated rats (P< 0.02). In Dex- and Dex + RA-treated rats, we observed increased hysteresis ratios (P≤ 0.006), air trapping (P< 0.05), and lung volumes at 5 and 13.5 cmH2O pressure (P< 0.001) and decreased elastic recoil (P< 0.007). The effect of Dex on elastic recoil was greater in female than in male rats (P= 0.006). Despite impaired septation, O2saturation was not compromised in Dex- or Dex + RA-treated rats. Thus lung function changes induced by Dex treatment during alveolarization were not prevented by concomitant treatment with RA.