An oncospace for human cancers
An oncospace for human cancers
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DOI：
10.1002/bies.202200215
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发表时间：
2023-03-02
期刊：
影响因子：
4
通讯作者：
Sole, Ricard
中科院分区：
文献类型：
--
作者：
Aguade-Gorgorio, Guim;Costa, Jose;Sole, Ricard
人类癌症包括具有不同进展模式和对治疗的反应的一系列异质性疾病。然而，它们都是在宿主环境中发展的，这限制了它们的自然历史。由于它发生在生物体的多样性中，人们可以推测癌症多元宇宙中存在秩序。有没有一种方法可以在可能的范围内捕获广泛的肿瘤类型？在这里，我们定义了oncospace，一个坐标系统，整合了癌症复杂性的生态，进化和发展的组成部分。肿瘤的空间位置由其沿着这三个轴沿着离开健康组织而产生，并且进展轨迹告知关于在癌症亚型中驱动恶性肿瘤的成分。我们假设oncospace拓扑结构编码了关于肿瘤发生途径、亚型预后和治疗机会的新信息：考虑如何将肿瘤推向oncospace中空的进化死胡同，治疗设计可能会受益。
Human cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity of organisms, one can conjecture that there is order in the cancer multiverse. Is there a way to capture the broad range of tumor types within a space of the possible? Here we define the oncospace, a coordinate system that integrates the ecological, evolutionary and developmental components of cancer complexity. The spatial position of a tumor results from its departure from the healthy tissue along these three axes, and progression trajectories inform about the components driving malignancy across cancer subtypes. We postulate that the oncospace topology encodes new information regarding tumorigenic pathways, subtype prognosis, and therapeutic opportunities: treatment design could benefit from considering how to nudge tumors toward empty evolutionary dead ends in the oncospace.