Multidrug-Resistant Candida haemulonii and C. auris, Tel Aviv, Israel.
Multidrug-Resistant Candida haemulonii and C. auris, Tel Aviv, Israel.
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DOI：
10.3201/eid2302.161486
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发表时间：
2017-02
影响因子：
11.8
通讯作者：
Finn T
中科院分区：
文献类型：
--
作者：
Ben-Ami R;Berman J;Novikov A;Bash E;Shachor-Meyouhas Y;Zakin S;Maor Y;Tarabia J;Schechner V;Adler A;Finn T
临床特征和实验推断的毒力表明C.耳具有更大的致命潜力。耳念珠菌和C. Haemulonii是密切相关的多药耐药的新兴真菌病原体，其不容易用表型测定区分。我们学习了C。auris和C. Haemulonii临床分离物来自以色列中部的2家医院。C. 5例院内血流感染患者分离出耳念珠菌，C.在外周血管疾病诊所发现haemulonii是腿部伤口的定植者。局部使用咪康唑和患者之间的密切接触与C。Haemulonii传播C.在小鼠感染模型中，auris表现出更高的耐热性、毒力和ATP依赖的药物外排活性。海缪龙。核糖体DNA序列比较发现，C。来自以色列的auris菌株与来自东亚、南非和科威特的分离株在遗传学上不同，而C.来自不同国家的血吸虫菌株之间存在着密切的联系。我们的研究结果强调了C.并强调有必要限制其传播。
Clinical features and experimentally deduced virulence indicate that C. auris has the greater lethal potential. Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C. haemulonii transmission. C. auris exhibited higher thermotolerance, virulence in a mouse infection model, and ATP-dependent drug efflux activity than C. haemulonii. Comparison of ribosomal DNA sequences found that C. auris strains from Israel were phylogenetically distinct from isolates from East Asia, South Africa and Kuwait, whereas C. haemulonii strains from different countries were closely interrelated. Our findings highlight the pathogenicity of C. auris and underscore the need to limit its spread.