Brain development during childhood and adolescence: a longitudinal MRI study
Brain development during childhood and adolescence: a longitudinal MRI study
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DOI：
10.1038/13158
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发表时间：
1999-10-01
影响因子：
25
通讯作者：
Rapoport, JL
中科院分区：
文献类型：
--
作者：
Giedd, JN;Blumenthal, J;Rapoport, JL
儿科神经影像学研究1、2、3、4、5，到目前为止仅为横断面研究，确定了4至20岁之间皮质灰质的线性减少和白色物质的增加。在这项大规模的纵向儿科神经影像学研究中，我们证实了白色物质的线性增加，但表现出皮质灰质的非线性变化，青春期前增加，青春期后减少。皮质灰质的这些变化具有区域特异性，额叶和顶叶的发育曲线在12岁左右达到峰值，颞叶的发育曲线在16岁左右达到峰值，而枕叶的皮质灰质持续增加，直到20岁。
Pediatric neuroimaging studies 1, 2, 3, 4, 5, up to now exclusively cross sectional, identify linear decreases in cortical gray matter and increases in white matter across ages 4 to 20. In this large-scale longitudinal pediatric neuroimaging study, we confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease. These changes in cortical gray matter were regionally specific, with developmental curves for the frontal and parietal lobe peaking at about age 12 and for the temporal lobe at about age 16, whereas cortical gray matter continued to increase in the occipital lobe through age 20.