Effect of a western-style diet fortified with increased calcium and vitamin D on mammary gland of C57Bl/6 mice
Effect of a western-style diet fortified with increased calcium and vitamin D on mammary gland of C57Bl/6 mice
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DOI：
10.1089/jmf.2007.619
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发表时间：
2008-06-01
影响因子：
2.4
通讯作者：
Lipkin, Martin
中科院分区：
文献类型：
--
作者：
Kurihara, Naoto;Fan, Kunhua;Lipkin, Martin
我们之前报道过喂食西式饮食（WD）后C57Bl/6小鼠乳腺增生；在补充钙和维生素D-3后，这些发现有所减少。我们现在再次从两个来源增加钙和维生素D3来强化WD:(1)食物来源，富含钙和维生素D-3的酸奶（WDy饮食）或(2)直接向WD添加钙和维生素D-3 （WDCaD饮食）。喂养6个月后，进食WD的小鼠乳腺导管数量高于进食WDy的小鼠(216.0 vs. 202.7， P
We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased after supplementing WD with increased calcium and vitamin D-3. We now again fortified WD with increased calcium and vitamin D3 from two sources: (1) a food source, calcium- and vitamin D-3-enriched yogurt (WDy diet) or (2) adding calcium and vitamin D-3 directly to WD (WDCaD diet). After 6 months of feeding the number of mammary ducts was higher in mice consuming WD compared to WDy (216.0 vs. 202.7, P