Solubility of Lansoprazole in different solvents
Solubility of Lansoprazole in different solvents
复制标题
兰索拉唑在不同溶剂中的溶解度
DOI：
10.1016/j.fluid.2012.06.011
复制
发表时间：
2012-10-15
影响因子：
2.6
通讯作者：
Qi, Minghui
中科院分区：
文献类型：
--
作者：
Hong, Minghuang;Xu, Lehui;Qi, Minghui
采用激光监测技术，在283.15 ~ 318.15K温度范围内，测定了兰索拉唑在10种纯溶剂及二元混合溶剂（异丙醇）中的溶解度。实验数据拟合使用修改的Apelblat方程和两种变体的组合近理想二元溶剂/Redlich-Kister（CNIBS/R-K）模型。该模型被证明能很好地代表实验数据。计算结果表明，CNIBS/R-K模型的两个变体相比，变体2具有上级优势。采用van 't霍夫方程计算了兰索拉唑在所有纯溶剂和混合溶剂体系中的溶解焓和溶解熵。溶解过程是吸热和熵驱动的。(C)2012爱思唯尔有限公司版权所有。
By using a laser monitoring observation technique, the solubilities of Lansoprazole in ten pure solvents as well as in a binary solvent mixture (isopropyl alcohol) were measured in the temperature ranging from 283.15 to 318.15 K. The experimental data were fitted using the modified Apelblat equation and two variants of the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model. The models were proven to give good representations of the experimental data. Computational results showed that variant 2 was superior to the variant 1 after comparison between the two variants of CNIBS/R-K model. The solubility enthalpy and entropy of Lansoprazole in all pure solvents and the mixed solvent system were calculated using van't Hoff equation. The dissolving process was endothermic and entropy-driving. (C) 2012 Elsevier B.V. All rights reserved.