The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies.
The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies.
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DOI：
10.1093/database/bav074
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fox HS
中科院分区：
文献类型：
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作者：
Cserhati MF;Pandey S;Beaudoin JJ;Baccaglini L;Guda C;Fox HS
我们在此介绍了国家神经艾滋病组织联盟数据协调中心（NNTC-DCC）数据库，这是唯一可用的数据库，神经艾滋病研究，包含数据在一个集成的，标准化的形式。该数据库是与NNTC合作创建的，NNTC为研究人员提供人体组织和生物流体样本，以进行重点研究神经艾滋病。该数据库包含来自1206名受试者的实验数据集，用于以下类别（进一步细分为子类别）：基因表达，基因型，蛋白质，内外化学物质，形态计量学和其他（杂项）数据。该数据库还包含95项艾滋病毒相关研究的各种可下载数据和元数据，涵盖61名主要研究人员的170项检测。数据代表76种组织类型，25种测量类型和38种技术类型，总计33 017 407个数据点。我们使用伊萨平台来创建数据库，并开发一个可搜索的Web界面来查询数据。还提供了一个基因搜索工具，用于搜索与选定基因相关的NCBI GEO数据集。该数据库是手动管理的，具有许多用户友好的功能，并与NCBI，HUGO和PubMed数据库交叉链接。合格用户需要免费注册才能访问数据库。数据库URL：http://nntc-dcc.unmc.edu
We herein present the National NeuroAIDS Tissue Consortium-Data Coordinating Center (NNTC-DCC) database, which is the only available database for neuroAIDS studies that contains data in an integrated, standardized form. This database has been created in conjunction with the NNTC, which provides human tissue and biofluid samples to individual researchers to conduct studies focused on neuroAIDS. The database contains experimental datasets from 1206 subjects for the following categories (which are further broken down into subcategories): gene expression, genotype, proteins, endo-exo-chemicals, morphometrics and other (miscellaneous) data. The database also contains a wide variety of downloadable data and metadata for 95 HIV-related studies covering 170 assays from 61 principal investigators. The data represent 76 tissue types, 25 measurement types, and 38 technology types, and reaches a total of 33 017 407 data points. We used the ISA platform to create the database and develop a searchable web interface for querying the data. A gene search tool is also available, which searches for NCBI GEO datasets associated with selected genes. The database is manually curated with many user-friendly features, and is cross-linked to the NCBI, HUGO and PubMed databases. A free registration is required for qualified users to access the database. Database URL: http://nntc-dcc.unmc.edu