Role of autophagy in embryogenesis
Role of autophagy in embryogenesis
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DOI：
10.1016/j.gde.2014.03.010
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发表时间：
2014-08-01
影响因子：
4
通讯作者：
Aoyama, Minako
中科院分区：
文献类型：
--
作者：
Wada, Yoh;Sun-Wada, Ge-Hong;Aoyama, Minako
真核生物已经进化出多种失活大分子以维持其功能的机制。自噬--自噬的过程--导致细胞质成分的降解，从而导致亚细胞隔间的动态重塑、大分子的周转和循环，以及通过控制特定的细胞内信号通路来调节细胞活动。这一基本过程也涉及对饥饿和免疫挑战的全身反应，以及抗肿瘤和抗衰老。最近的研究也强调了自噬在胚胎发育中的重要作用。在这篇综述中，我们讨论了自噬在不同发育阶段的不同功能的新证据，重点是胚胎发生的早期事件。
Eukaryotes have evolved multiple mechanisms for inactivating macromolecules in order to maintain their functionality. Autophagy - the process of self-eating - leads to the degradation of cytoplasmic components for the dynamic remodeling of subcellular compartments, turnover and recycling of macromolecules, and regulation of cellular activity through the control of specific intracellular signaling pathways. This fundamental process is also implicated in systemic response to starvation and immune challenges, as well as anti-tumorigenesis and anti-senescence. Recent studies have also highlighted an important role for autophagy in embryonic development. In this review, we discuss the emerging evidence for the varied functions of autophagy at different stages of development, with an emphasis on the early events of embryogenesis.