Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
复制标题
肥胖和减肥干预后肠道微生物组和血清代谢组的变化。
DOI：
10.1038/nm.4358
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发表时间：
2017-07-01
期刊：
影响因子：
82.9
通讯作者：
Wang, Weiqing
中科院分区：
文献类型：
--
作者：
Liu, Ruixin;Hong, Jie;Wang, Weiqing
新出现的证据表明，肠道微生物群与人类肥胖有关。我们进行了一项全宏基因组关联研究和血清代谢组学分析，研究对象是瘦弱和肥胖的中国年轻人。我们确定了与肥胖相关的肠道微生物物种与循环代谢物的变化有关。肥胖人群谷氨酸发酵共生拟杆菌（Bacteroides thetaiotaomicron）丰度显著降低，且与血清谷氨酸浓度呈负相关。与此一致的是，灌胃B. thetaiotaomicron降低了小鼠血浆谷氨酸浓度，减轻了饮食引起的体重增加和肥胖。此外，通过减肥手术进行的减肥干预部分逆转了肥胖个体中与肥胖相关的微生物和代谢改变，包括B. the taiotaommicron丰度的降低和血清谷氨酸浓度的升高。我们的研究结果确定了肠道微生物群改变、循环氨基酸和肥胖之间以前未知的联系，这表明有可能通过靶向肠道微生物群来干预肥胖。
Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.