Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants.
Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants.
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母亲补充锌可降低秘鲁婴儿腹泻的发病率。
DOI：
10.1016/j.jpeds.2009.12.023
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Caulfield,LauraE
中科院分区：
文献类型：
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作者：
Iannotti,LoraL;Zavaleta,Nelly;León,Zulema;Huasquiche,Clara;Shankar,AnurajH;Caulfield,LauraE
目的探讨孕期补锌是否能降低婴儿发病率。研究设计1995~1997年在秘鲁利马郊区贫民窟进行了产前补锌的随机双盲对照试验。参与者被随机分配到每天补充锌(15 mg锌+60 mg铁+250μg叶酸)或安慰剂(60铁+250μg叶酸)，从妊娠10周到24周，直到产后1个月。从出生到12个月按月测量人体尺寸，从6到12个月每周测量发病率和膳食摄入量(n=421)。结果产前服用锌的婴儿腹泻的平均观察天数百分比(5.8%)比对照组(7.7%)减少(P=0.01)。在调整了婴儿年龄、母乳喂养、季节以及卫生和卫生相关因素后，产前补锌降低了婴儿出现持续7天以上的急性腹泻(OR 0.66，95%CI 0.43，0.99，P=0.04)和粪便粘液(OR 0.65，95%CI 0.46，0.92，P=0.01)的可能性。未检测到对呼吸道疾病、发热或皮肤状况的治疗效果。结论改善产前锌营养可保护12个月大的婴儿预防腹泻发病率。
OBJECTIVETo test whether zinc supplementation during pregnancy would reduce infant morbidity rates.STUDY DESIGNA double-blind, randomized controlled trial of prenatal zinc supplementation was conducted from 1995 to 1997 in a periurban slum of Lima, Peru. Participants were randomly assigned to receive daily supplementation with zinc (15 mg zinc + 60 mg iron + 250 μg folic acid) or placebo (60 iron + 250 μg folic acid) from 10 to 24 weeks gestation until 1 month postpartum. Anthropometry was measured monthly from birth through age 12 months, and morbidity and dietary intake were measured weekly from 6 to 12 months (n = 421).RESULTSThe average percentage of observation days with diarrhea among infants prenatally treated with zinc (5.8%) was reduced compared with infants in the control group (7.7%) (P = .01). Prenatal zinc supplementation reduced the likelihood of an infant experiencing diarrheal episodes of acute diarrhea lasting longer than 7 days (OR 0.66, 95% CI 0.43, 0.99, P = .04) and mucus in the stool (OR 0.65 95% CI 0.46, 0.92, P = .01) adjusting for infant age, breastfeeding, season, and hygiene and sanitation covariates. No treatment effects on respiratory illnesses, fever, or skin conditions were detected.CONCLUSIONSImproving prenatal zinc nutrition protected against diarrheal morbidity in infant offspring through 12 months of age.