Biomarkers of dairy fatty acids and risk of cardiovascular disease in the Multi-ethnic Study of Atherosclerosis.
Biomarkers of dairy fatty acids and risk of cardiovascular disease in the Multi-ethnic Study of Atherosclerosis.
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DOI：
10.1161/jaha.113.000092
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发表时间：
2013-07-18
影响因子：
5.4
通讯作者：
Mozaffarian D
中科院分区：
文献类型：
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作者：
de Oliveira Otto MC;Nettleton JA;Lemaitre RN;Steffen LM;Kromhout D;Rich SS;Tsai MY;Jacobs DR;Mozaffarian D
关于乳制品脂肪摄入在心血管疾病（CVD）中的作用的证据是混合的，不确定的。大多数早期的研究都使用自我报告的饮食摄入量，并专注于相对种族同质的人群。在多种族队列中，乳制品脂肪的循环生物标志物提供了乳制品脂肪摄入的客观测量，并有助于得出与不同饮食和CVD易感性人群相关的结论。在一项基线（2000 - 2002年）年龄为45 - 84岁的2837名美国成年人的多种族队列中，使用标准化方法测量磷脂脂肪酸（包括15：0、14：0和反式-16：1n7），并前瞻性判定CVD的发生率。自我报告的全脂奶制品和黄油摄入量与15：0的相关性最强，而不是14：0或反式16：1n7。在包括人口统计学、生活方式和饮食习惯的多变量模型中，SD单位每为15：0，CVD风险降低19%（风险比[95% CI] 0.81 [0.68至0.98]），冠心病（CHD）风险降低26%（0.74 [0.60至0.92]）。在14：0和trans-16：1n-7相互调整后，相关性得到加强，在调整潜在介质后相似。血浆磷脂14：0和trans-16：1n-7与CVD或CHD事件无显著相关性。在白色、黑人、西班牙裔和华裔美国人参与者中，所有发现都相似。血浆磷脂15：0（乳脂的生物标志物）与心血管疾病和冠心病的发病率呈负相关，而磷脂14：0和反式-16：1n-7则无相关性。这些发现支持需要进一步研究乳制品脂肪、乳制品特定脂肪酸和一般乳制品对CVD的影响。
Evidence regarding the role of dairy fat intake in cardiovascular disease (CVD) has been mixed and inconclusive. Most earlier studies have used self‐reported measures of dietary intake and focused on relatively racially homogeneous populations. Circulating biomarkers of dairy fat in a multiethnic cohort provide objective measures of dairy fat intake and facilitate conclusions relevant to populations with different diets and susceptibility to CVD. In a multiethnic cohort of 2837 US adults aged 45 to 84 years at baseline (2000–2002), phospholipid fatty acids including 15:0, 14:0, and trans‐16:1n7 were measured using standardized methods, and the incidence of CVD prospectively adjudicated. Self‐reported whole‐fat dairy and butter intakes had strongest associations with 15:0, rather than 14:0 or trans‐16:1n7. In multivariate models including demographics and lifestyle and dietary habits, each SD‐unit of 15:0 was associated with 19% lower CVD risk (hazard ratio [95% CI] 0.81 [0.68 to 0.98]) and 26% lower coronary heart disease (CHD) risk (0.74 [0.60 to 0.92]). Associations were strengthened after mutual adjustment for 14:0 and trans‐16:1n‐7 and were similar after adjustment for potential mediators. Plasma phospholipid 14:0 and trans‐16:1n‐7 were not significantly associated with incident CVD or CHD. All findings were similar in white, black, Hispanic, and Chinese American participants. Plasma phospholipid 15:0, a biomarker of dairy fat, was inversely associated with incident CVD and CHD, while no association was found with phospholipid 14:0 and trans‐16:1n‐7. These findings support the need for further investigation of CVD effects of dairy fat, dairy‐specific fatty acids, and dairy products in general.