Abnormal nodal flow precedes situs inversus in iv and inv mice
Abnormal nodal flow precedes situs inversus in iv and inv mice
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DOI：
10.1016/s1097-2765(00)80197-5
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发表时间：
1999-10-01
期刊：
影响因子：
16
通讯作者：
Hirokawa, N
中科院分区：
文献类型：
--
作者：
Okada, Y;Nonaka, S;Hirokawa, N
我们检查了具有良好特征的小鼠突变体的节流，内脏倒置（iv）和胚胎翻转倒置（inv），发现它们的侧边性缺陷总是伴随着节流异常。在随机侧侧突变体iv中，节纤毛不动，节流缺失。在逆位突变体（inv）中，节纤毛是可运动的，但只能产生非常微弱的向左节流。这些结果一致地支持我们的假设，即节点流产生假定的形态发生梯度并触发第一个L-R决定事件。
We examined the nodal flow of well-characterized mouse mutants, inversus viscerum (iv) and inversion of embryonic turning (inv), and found that their laterality defects are always accompanied by an abnormality in nodal flow. In a randomized laterality mutant, iv, the nodal cilia were immotile and the nodal flow was absent. In a situs inversus mutant, inv, the nodal cilia was motile but could only produce very weak leftward nodal flow. These results consistently support our hypothesis that the nodal flow produces the gradient of putative morphogen and triggers the first L-R determination event.