In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles
In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles
复制标题
DOI：
10.1016/j.jmmm.2005.02.036
复制
发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Iro, H
中科院分区：
文献类型：
--
作者：
Alexiou, C;Jurgons, R;Iro, H
磁性药物靶向是一种局部给药系统。电镜图片记录了体外细胞内空间的铁磁流体富集。用磁性纳米颗粒结合米托蒽醌在VX2荷瘤兔体内进行实验。磁性药物靶向后的高压液相色谱（HPLC）分析显示，与常规全身化疗相比，化疗药物在肿瘤区域的浓度增加。(c) 2005 Elsevier B.V.版权所有
Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy. (c) 2005 Elsevier B.V. All rights reserved.