Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans
Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans
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DOI：
10.1093/cercor.bhi114
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发表时间：
2006-03-01
期刊：
影响因子：
3.7
通讯作者：
Kakigi, R
中科院分区：
文献类型：
--
作者：
Inui, K;Tsuji, T;Kakigi, R
振动触觉刺激缓解疼痛的机制还不清楚，特别是在人类中。我们记录了大脑皮层对成对伤害性刺激的磁反应，（表皮内电刺激，IES）和无害（经皮电刺激，结果表明，当TS比IES延迟20-60 ms，提前0- 500 ms时，IES诱发的反应明显减弱（CTI = -60到500 ms）。由于IES诱发的信号到达脊髓（CTI = -60至-20 ms条件）和皮层（-60和-40 ms条件）早于TS诱发的信号，本研究结果表明，皮层对伤害性刺激的反应可以被皮层水平的无害触觉刺激抑制，在脊髓水平的贡献最小。
The mechanisms by which vibrotactile stimuli relieve pain are not well understood, especially in humans. We recorded cortical magnetic responses to paired noxious (intra-epidermal electrical stimulation, IES) and innocuous (transcutaneous electrical stimulation, TS) stimuli applied to the back at a conditioning-test interval (CTI) of -500 to 500 ms. Results showed that IES-induced responses were remarkably attenuated when TS was applied 20-60 ms later and 0-500 ms earlier than IES (CTI = -60 to 500 ms). Since the signals evoked by IES reached the spinal cord (CTI = -60 to -20 ms conditions) and the cortex (-60 and -40 ms condition) earlier than those evoked by TS, the present results indicate that cortical responses to noxious stimuli can be inhibited by innocuous tactile stimuli at the cortical level, with minimal contribution at the spinal level.