Obesity, insulin resistance, and microvessel density
Obesity, insulin resistance, and microvessel density
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DOI：
10.1080/10739680701282945
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发表时间：
2007-01-01
期刊：
影响因子：
2.4
通讯作者：
Frisbee, Jefferson C.
中科院分区：
文献类型：
--
作者：
Frisbee, Jefferson C.
在全世界发达经济体中，超重/肥胖状况的发病率和患病率不断增加，这对增加患病个体中血糖控制受损或胰岛素抵抗以及最终外周血管疾病（PVD）的风险具有巨大影响。这给这些社会带来了巨大的经济和社会负担，增加了医疗保健费用，损失了生产力，并部分由于渐进性PVD导致个人生活质量下降。PVD的特征在于血管系统不能相对于组织和器官的代谢需求充分灌注组织和器官，PVD部分地是微血管网络的结构重构的函数，使得组织内的微血管和毛细血管的密度降低到低于正常条件下的密度，具有对质量运输和交换过程产生深远负面影响的可能性。该综述从PVD的角度讨论了肥胖“肥胖症”的严重程度，以及肥胖、胰岛素抵抗状态对组织/器官微血管密度的影响。额外的材料进行审查，解决改善治疗，主要是运动训练，钝化微血管损失的肥胖，胰岛素抵抗的个人，和潜在的机械贡献者，值得相当大的未来调查。
The growing incidence and prevalence of the overweight/obese condition across developed economies worldwide has an enormous impact on increasing the risk for the development of impaired glycemic control or insulin resistance and ultimately peripheral vascular disease (PVD) in afflicted individuals. This places an enormous economic and social burden on these societies, in terms of additional health care costs and lost productivity and through a reduction in the quality of life of the individual owing, in part, to the progressive PVD. Characterized by an inability of the vascular systems to adequately perfuse tissues and organs relative to their metabolic demand, PVD is in part a function of a structural remodeling of the microvascular networks such that the density of microvessel and capillaries within tissues is reduced below that under normal conditions, with the potential for profound negative impacts on the processes of mass transport and exchange. The review discusses the severity of the obesity "epidemic'' from the perspective of PVD and the effects of the development of the obese, insulin-resistant condition on tissue/organ microvessel density. Additional material is reviewed that addresses ameliorative treatments, primarily exercise training, on blunting microvessel loss in the obese, insulin-resistant individual, and on potential mechanistic contributors that warrant considerable future investigation.