Dengue

Dengue
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DOI:
10.1016/s0140-6736(14)60572-9
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发表时间:
2015-01-31
期刊:
影响因子:
168.9
通讯作者:
Harris, Eva
Harris, Eva
中科院分区:
医学1区
文献类型:
--
作者:
Guzman, Maria G.;Harris, Eva

文献摘要

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在过去几十年中,登革热病毒在国家内部和跨区域迅速传播,导致登革热流行和严重疾病的频率增加,许多热带国家出现多种登革热病毒血清型的高流行,以及欧洲和美国的本地传播。今天,登革热被认为是人类最流行和传播最迅速的蚊媒病毒性疾病。重要的是,在过去十年中,对登革热病毒学、发病机制和免疫学的研究以及抗病毒药物、疫苗和新的病媒控制战略的开发也出现了激增,这些都可以对登革热的控制和预防产生积极影响。
Dengue viruses have spread rapidly within countries and across regions in the past few decades, resulting in an increased frequency of epidemics and severe dengue disease, hyperendemicity of multiple dengue virus serotypes in many tropical countries, and autochthonous transmission in Europe and the USA. Today, dengue is regarded as the most prevalent and rapidly spreading mosquito-borne viral disease of human beings. Importantly, the past decade has also seen an upsurge in research on dengue virology, pathogenesis, and immunology and in development of antivirals, vaccines, and new vector-control strategies that can positively impact dengue control and prevention.