Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus.
Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus.
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尿前列腺素升高和阿司匹林对红斑狼疮肾功能的影响。
DOI：
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发表时间：
1978
影响因子：
39.2
通讯作者：
Paul H. Plotz
中科院分区：
文献类型：
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作者：
Robert P. Kimberly;John R. Gill;R. Bowden;H. R. Keiser;Paul H. Plotz
我们研究了7名女性系统性红斑狼疮患者尿中免疫反应性前列腺素E样物质（iPGE）的排泄和肾功能，以评估服用阿司匹林患者尿iPGE与血清肌酐升高之间的关系。红斑狼疮患者尿iPGE的平均治疗前排泄量为42.7 +/- 6.4 ng/h，显著高于正常人的29.0 +/- 1.9 ng/h（P <0.02）。服用阿司匹林后，尿iPGE平均下降45%（P <0.001）。血清肌酐和血尿素氮升高证实了我们先前的临床观察结果。肌酐清除率平均下降18%（P <0.001），菊粉清除率下降14%（P <0.005）;对氨基马尿酸清除率下降29%（P <0.005）。尿iPGE下降先于肌酐清除率下降，但与肌酐清除率显著相关（r = 0.78; P <0.001）。阿司匹林停药后，观察到的变化迅速逆转。这些数据表明，在这些尿iPGE排泄量高的患者中，阿司匹林引起肾功能的显著变化，这可能是通过抑制前列腺素合成介导的。
We studied the urinary excretion of immunoreactive prostaglandin E-like material (iPGE) and renal function in seven women with systemic lupus erythematosus to evaluate the relation between urinary iPGE and the increase in serum creatinine in patients taking aspirin. The mean pretreatment excretion of urinary iPGE in patients with lupus erythematosus, 42.7 +/- 6.4 ng/h, was significantly higher than the value of 29.0 +/- 1.9 ng/h for normal subjects (P less than 0.02). With aspirin, the urinary iPGE decreased an average of 45% (P less than 0.001). Increases in serum creatinine and blood urea nitrogen confirmed our previous clinical observations. The concomitant mean fall in creatinine clearance of 18% (P less than 0.001) was accompanied by a 14% decrease in inulin clearance (P less than 0.005); p-aminohippurate clearance fell 29% (P less than 0.005). The decline in urinary iPGE preceded the fall in creatinine clearance but was significantly correlated with it (r = 0.78; P less than 0.001). The observed changes reversed rapidly when aspirin was stopped. These data show that, in these patients with high urinary iPGE excretion, aspirin causes significant changes in renal function that may be mediated by the inhibition of prostaglandin synthesis.