LRP: a multifunctional scavenger and signaling receptor
LRP: a multifunctional scavenger and signaling receptor
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DOI：
10.1172/jci13992
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发表时间：
2001-09-01
影响因子：
15.9
通讯作者：
Strickland, DK
中科院分区：
文献类型：
--
作者：
Herz, J;Strickland, DK
LDL受体相关蛋白（LRP）比LDL受体基因家族（一个古老的内吞受体家族）的其他成员大，但结构相似（1-3）。而LDL受体，该家族的创始成员，似乎只在脂蛋白代谢中起作用，LRP和该家族的其他成员似乎具有其他不同的功能。在这篇文章中，我们将重点介绍LRP的各种生物学作用，其中包括脂质代谢中的功能，以及蛋白酶和蛋白酶抑制剂的稳态，病毒和毒素的细胞进入，溶酶体酶的激活，细胞信号转导和神经传递。
The LDL receptor–related protein (LRP) is larger than but structurally similar to other members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3). Whereas the LDL receptor, the founding member of this family, appears to act solely in lipoprotein metabolism, the LRP and other members of this family appear to have other distinct functions. In this article, we will focus on the diverse biological roles of the LRP, which include functions in lipid metabolism, and also in the homeostasis of proteinases and proteinase inhibitors, cellular entry of viruses and toxins, activation of lysosomal enzymes, cellular signal transduction, and neurotransmission.