Association between BHMT gene rs3733890 polymorphism and cancer risk: evidence from a meta-analysis.
Association between BHMT gene rs3733890 polymorphism and cancer risk: evidence from a meta-analysis.
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BHMT 基因 rs3733890 多态性与癌症风险之间的关联：来自荟萃分析的证据
DOI：
10.2147/ott.s103901
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发表时间：
2016
影响因子：
4
通讯作者：
Liang C
中科院分区：
文献类型：
--
作者：
Xu Y;Yan C;Hao Z;Zhou J;Fan S;Tai S;Yang C;Zhang L;Liang C
甜菜碱-同型半胱氨酸甲基转移酶(BHMT)基因在过去的几十年里引起了人们的极大关注。越来越多的临床和遗传学研究认为BHMT rs3733890基因多态可能与乳腺癌和卵巢癌的发病风险有关。由于尚未得出一致的结论，我们通过荟萃分析对BHMT rs3733890基因多态与癌症风险进行了最新总结。这些文章来自PubMed、谷歌学者和CNKI(中文)数据库，截至2015年12月。然后，通过阅读标题和摘要来确定相关性，并通过进一步阅读全文来筛选不合格的文章。使用优势比(OR)和相应的95%可信区间(CI)来评估结果。在分析收集的187篇文章中，7项研究包括总共2,832例病例和3,958名对照，以评估BHMT rs3733890基因多态与癌症风险易感性的关系。异质性检验无显著差异。此外，病例组和对照组的−基因742G和Gt；A多态与宫颈癌的易感性无统计学差异(AvsG：OR=0.641，95%CI=0.445~0.923，P=0.017；AA+AG vsGG：OR=0.579，95%CI=0.362~0.924，P=0.022)。此外，当通过种族和基因分型方法进行分层分析时，没有发现统计上显著的关联。BHMT基因rs3733890多态对头颈部鳞状细胞癌、乳腺癌、卵巢癌、结直肠腺瘤和肝癌的易感性无明显影响。相反，我们发现BHMT−742G>；A多态在宫颈癌发病中具有保护作用。未来包括更大样本量的精心设计的研究将有理由验证我们的发现。
The gene betaine-homocysteine methyltransferase (BHMT) has drawn much attention during the past decades. An increasing number of clinical and genetic investigations have supposed that BHMT rs3733890 polymorphism might be associated with risk of breast cancer and ovarian cancer. As no consistent conclusion has been achieved, we conducted an up-to-date summary of BHMT rs3733890 polymorphism and cancer risk through a meta-analysis. The articles were collected from PubMed, Google Scholar, and CNKI (Chinese) databases up to December 2015. Then, the correlations were determined by reading the titles and abstracts and by further reading the full text to filter the unqualified articles. Odds ratio (OR) and the corresponding 95% confidence intervals (CI) were used to assess the results. Among 187 articles collected in the analysis, seven studies with a total of 2,832 cases and 3,958 controls were included for evaluation of the association between BHMT rs3733890 polymorphism and susceptibility of cancer risk. The heterogeneity test showed no significant differences. Furthermore, we found that BHMT −742G>A polymorphism in case and control groups showed no statistically significant association with susceptibility in various cancer types except for uterine cervical cancer (A vs G: OR =0.641, 95% CI =0.445–0.923, P=0.017; AA+AG vs GG: OR =0.579, 95% CI =0.362–0.924, P=0.022). In addition, no statistically significant association was uncovered when stratification analyses were conducted by ethnicity and genotyping methods. Our results have shown no obvious evidence that rs3733890 polymorphism in BHMT gene affected the susceptibility of head and neck squamous cell carcinoma, breast cancer, ovarian cancer, colorectal adenoma, and liver cancer. In contrast, we found the protective role of BHMT −742G>A polymorphism in uterine cervical cancer incidence. Future well-designed studies comprising larger sample size are warranted to verify our findings.
影响因子：
10.6
作者：
Moskvina, Valentina;Craddock, Nick;Mueller-Myhsok, Bertram;Kam-Thong, Tony;Green, Elaine;Holmans, Peter;Owen, Michael J.;O'Donovan, Michael C.
通讯作者：
O'Donovan, Michael C.