A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE).
A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE).
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DOI：
10.1016/j.neuroimage.2013.01.038
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发表时间：
2013-05-15
期刊：
影响因子：
5.7
通讯作者：
Song, Allen W.
中科院分区：
文献类型：
--
作者：
Chen, Nan-kuei;Guidon, Arnaud;Chang, Hing-Chiu;Song, Allen W.
关键词：
扩散加权磁共振成像（DWI）数据大多是通过单次回波平面成像（EPI）获得的，以尽量减少运动引起的伪影。然而，在单镜头EPI中，即使合并了平行成像（通常以2的加速因子），空间分辨率也受到固有的限制。多镜头采集策略可以潜在地实现更高的空间分辨率和保真度，但它们通常容易受到运动诱导的相位误差的影响，这些相位误差会因扩散敏化梯度而加剧，从而导致重建图像无法使用。研究表明，利用导航回波可以纠正弹间相位变化，但代价是成像吞吐量。为了解决这些问题，研究人员开发了一种新的、鲁棒的多镜头DWI技术，称为多路灵敏度编码（MUSE），该技术可以在不使用导航回波的情况下，可靠地、固有地校正非线性镜头到镜头的相位变化。在3台特斯拉磁共振成像系统上，对健康成人志愿者进行了MUSE技术的实验验证。这项新开发的技术对于在神经科学研究中以高空间分辨率绘制大脑结构和连接具有很高的价值。
Diffusion weighted magnetic resonance imaging (DWI) data have been mostly acquired with single-shot echo-planar imaging (EPI) to minimize motion induced artifacts. The spatial resolution, however, is inherently limited in single-shot EPI, even when the parallel imaging (usually at an acceleration factor of 2) is incorporated. Multi-shot acquisition strategies could potentially achieve higher spatial resolution and fidelity, but they are generally susceptible to motion-induced phase errors among excitations that are exacerbated by diffusion sensitizing gradients, rendering the reconstructed images unusable. It has been shown that shot-to-shot phase variations may be corrected using navigator echoes, but at the cost of imaging throughput. To address these challenges, a novel and robust multi-shot DWI technique, termed multiplexed sensitivity-encoding (MUSE), is developed here to reliably and inherently correct nonlinear shot-to-shot phase variations without the use of navigator echoes. The performance of the MUSE technique is confirmed experimentally in healthy adult volunteers on 3 Tesla MRI systems. This newly developed technique should prove highly valuable for mapping brain structures and connectivities at high spatial resolution for neuroscience studies.
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