The role of RNA interference in heterochromatic silencing
The role of RNA interference in heterochromatic silencing
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DOI：
10.1038/nature02875
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发表时间：
2004-09-16
期刊：
影响因子：
64.8
通讯作者：
Martienssen, R
中科院分区：
文献类型：
--
作者：
Lippman, Z;Martienssen, R
75 年前被发现后不久，异染色质（一种致密的染色体物质）被发现可以沉默基因。但它在调节基因表达方面的重要性存在争议。长期以来，异染色质被认为是惰性的，现在已知它会产生小 RNA，通过 RNA 干扰，指导异染色质重复序列和转座元件中蛋白质和 DNA 的修饰。因此，异染色质已成为基因表达、染色体行为和进化的表观遗传调控的关键因素。
Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.