Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects
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DOI：
10.1152/ajpregu.00474.2002
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发表时间：
2003-07-01
影响因子：
2.8
通讯作者：
Leibel, RL
中科院分区：
文献类型：
--
作者：
Rosenbaum, M;Vandenborne, K;Leibel, RL
维持降低或升高的体重导致体力活动中消耗的能量分别减少或增加，体力活动定义为24小时能量消耗，不包括静息能量消耗和进食的热效应，超出可归因于体重变化的能量。我们用分级踏车测力法检测了30名受试者的骨骼肌工作效率，在某些受试者中，用磁共振波谱（MRS）检测了运动期间腓肠肌ATP通量的速率（男性，15名女性），初始体重和低于初始体重10%，8名受试者（7只雄性，1只雌性），以确定改变体重时骨骼肌工作效率的变化是否与体力活动中消耗的能量变化相关。在体重减轻时，踏车测力计[平均（SD）变化= +26.5（26.7）%，P < 0.001]和MRS [ ATP通量变化= -15.2（23.2）%，P = 0.044]研究中的肌肉工作效率均增加。体重增加导致测力法测定的肌肉工作效率降低[平均（SD）变化= -17.8（20.5）%，P = 0.043]。体重改变时肌肉效率的变化占体力活动每日能量消耗变化的35%。
Maintenance of reduced or elevated body weight results in respective decreases or increases in energy expended in physical activity, defined as 24-h energy expenditure excluding resting energy expenditure and the thermic effect of feeding, beyond those attributable to weight change. We examined skeletal muscle work efficiency by graded cycle ergometry and, in some subjects, rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy (MRS), in 30 subjects (males, 15 females) at initial weight and 10% below initial weight and in 8 subjects (7 males, 1 female) at initial weight and 10% above initial weight to determine whether changes in skeletal muscle work efficiency at altered body weight were correlated with changes in the energy expended in physical activity. At reduced weight, muscle work efficiency was increased in both cycle ergometry [mean (SD) change = +26.5 (26.7)%, P < 0.001] and MRS [ ATP flux change = -15.2 (23.2)%, P = 0.044] studies. Weight gain resulted in decreased muscle work efficiency by ergometry [mean (SD) change = -17.8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity.