Children with chronic renal failure in the Federal Republic of Germany: I. Epidemiology, modes of treatment, survival. Arbeits- gemeinschaft für Pädiatrische Nephrologie.
Children with chronic renal failure in the Federal Republic of Germany: I. Epidemiology, modes of treatment, survival. Arbeits- gemeinschaft für Pädiatrische Nephrologie.
复制标题
德意志联邦共和国患有慢性肾衰竭的儿童：I.流行病学、治疗方式、生存。
作者：
K. Pistor;H. Olbing;K. Schärer
通过在联邦共和国德国进行的一项全国性回顾性调查，获得了16岁以下慢性肾衰竭（CRF）儿童的流行病学数据。在4年期间（1972-1975年），当涉及100万相同年龄的人口时，每年发生6例新的CRF病例。终末前CRF（血清肌酐大于2 mg/dl至终末期）的发生率为4.4，患病率为每年每百万人6.4。分析了1972年至1977年6年期间终末期CRF的发生率，随时间推移仅略有增加（从每年每百万同龄人4.4例增加至5.4例）。在观察期间，每年接受肾脏替代治疗的终末期CRF儿童比例从27%增加到79%，直至10岁，10至16岁从80%增加到96%。终末期CRF患者的存活率从1972年的11.9/100万显著上升到1977年的22.0/100万。1977年底，46%接受肾脏替代治疗的儿童患者移植肾功能正常，而1972年为38%。随着肾移植数量的增加，从首次透析到移植的等待时间缩短。在随后的两个4年期间，透析和移植后的患者生存率显著上升。（250字处删节）
By a nation-wide retrospective survey in the Federal Republic of Germany, epidemiological data were obtained on children with chronic renal failure (CRF) up to the age of 16.0 years. During a 4-year period (1972-1975), an incidence of 6 new cases per year of CRF occurred when referring to a 1 million population of the same age. The incidence of preterminal CRF (serum creatinine greater than 2 mg/dl to end-stage) was 4.4 and its prevalence 6.4 per million per year. The incidence of terminal CRF, analyzed for a 6-year period from 1972 to 1977 increased only slightly with time (from 4.4 to 5.4 per million of the same age per year). The proportion of children with terminal CRF admitted yearly for renal replacement therapy increased during the observation time from 27% to 79% up to the age of 10 years and from 80% to 96% between 10 and 16 years of age. The number of patients alive with terminal CRF rose significantly from 11.9 in 1972 to 22.0 per 1 million of the same age in 1977. At the end of 1977, 46% of all pediatric patients on renal replacement therapy had a functioning graft, compared to 38% in 1972. The increasing number of renal transplantations was accompanied by shortening of the waiting period from first dialysis to grafting. The patient survival on dialysis and after transplantation rose significantly during two subsequent 4-year periods.(ABSTRACT TRUNCATED AT 250 WORDS)