Combining morphine and ibuprofen does not improve pain control compared with using either drug alone following musculoskeletal injury in children.
Combining morphine and ibuprofen does not improve pain control compared with using either drug alone following musculoskeletal injury in children.
复制标题
与单独使用任一药物相比，吗啡和布洛芬联合使用并不能改善儿童肌肉骨骼损伤后的疼痛控制。
DOI：
10.1136/eb-2018-102918
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发表时间：
2018
影响因子：
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通讯作者：
Groenewald,CorneliusBotha
中科院分区：
文献类型：
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作者：
Groenewald,CorneliusBotha
作者假设布洛芬和吗啡与单独使用任何一种药物相比，可以提供更好的疼痛控制。为了验证这一假设，他们招募了501名6-17岁的儿童，他们在急诊科就诊时患有轻度至中度肌肉骨骼损伤。他们将参与者随机分配到三个研究组之一：（1）布洛芬+吗啡，（2）单独使用布洛芬和（3）单独使用吗啡（布洛芬和吗啡组有适当的安慰剂）。关注的主要结局是在研究药物给药后60分钟，通过视觉疼痛量表（范围0-100 mm）测量，三组中每一组实现疼痛减轻至30 mm或更小的儿童比例（%）。这是一种既定的测量疼痛缓解的方法，与先前的研究一致。1正如预期的那样，随机化导致三组在基线时相等，具有相似的年龄和性别分布，疼痛评级和损伤类型。
MethodsThe authors hypothesised that ibuprofen and morphine would provide better pain control compared with using either medication alone. To test this hypothesis, they recruited 501 children aged 6–17 years with mild-to-moderate musculoskeletal injuries on presentation to the emergency department. They randomly assigned participants to one of three study groups:(1) ibuprofen+ morphine,(2) ibuprofen alone and (3) morphine alone (the ibuprofen and morphine groups had appropriate placebos). The main outcome of interest was the proportion (%) of children in each of the three groups achieving a reduction of pain, as measured by the Visual Analogue Pain Scale (range 0–100 mm), to 30 mm or less at 60 min following administration of the study medication. This is an established way of measuring pain relief consistent with previous studies. 1 As expected, randomisation resulted in the three groups being equal at baseline with similar age and gender distribution, pain ratings and injury types.