Effects of systemic and regional chemotherapy after hepatic resection for colorectal metastases
Effects of systemic and regional chemotherapy after hepatic resection for colorectal metastases
复制标题
结直肠转移癌肝切除术后全身及区域化疗的效果
DOI：
10.1007/bf02303481
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发表时间：
1998
影响因子：
3.7
通讯作者：
K. Aiba
中科院分区：
文献类型：
--
作者：
N. Kokudo;M. Seki;H. Ohta;K. Azekura;M. Ueno;Tadao Sato;Akihito Moroguchi;T. Matsubara;Takashi Takahashi;T. Nakajima;K. Aiba
摘要背景：虽然肝切除术对结直肠转移的生存获益已经确立，但关于肝切除术后辅助化疗的意义仍存在一些争议。
AbstractBackground: Although the survival benefit of hepatic resection for colorectal metastasis has been established, some controversy remains regarding the significance of adjuvant chemotherapy after hepatic resection.
Methods: One hundred thirty-two consecutive patients who had liver resection for colorectal metastasis at our hospital between 1980 and 1997 were studied. After curative hepatic resection, 37 patients underwent systemic chemotherapy, administered orally or intraportally. Forty patients had no adjuvant chemotherapy. The chemotherapeutic agents used for oral administration were uracil and Tegafur or Tegafur alone. Mitomycin C (MMC) or 5-FU was used for IV chemotherapy. Combinations of 5-FU/leucovorin or MMC/5-FU (doxorubicin) were used for regional chemotherapy. Univariate and multivariate analyses were applied to test the significance of adjuvant chemotherapy for patient survival or disease-free survival.
Results: Overall 5-year survival was 42.2% (95% CL: 31.2%, 53.2%). Among the possible prognostic factors studied, univariate analysis showed a significant difference in survival based on the number of tumors and lymph node metastases in the hepatic hilum. There was a significant difference in disease-free survival based on adjuvant chemotherapy and lymph node metastasis. The multivariate analysis for patient survival selected four prognostic factors (P<.05), including adjuvant chemotherapy, lymph node metastasis, disease-free interval, and tumor size. The multivariate analysis for disease-free survival selected adjuvant chemotherapy, lymph node metastasis, and disease-free interval as significant factors. The most common recurrence site was remnant liver, regardless of adjuvant chemotherapy.
Conclusions: Adjuvant chemotherapy significantly improved survival and disease-free survival after hepatic resection for colorectal metastases. It did not decrease recurrence rate in the remnant liver.
肝切除术治疗转移性结直肠癌。
影响因子：
3.8
作者：
Iwatsuki,S;Esquivel,CO;Gordon,RD;Starzl,TE
通讯作者：
Starzl,TE
影响因子：
45.3
作者：
HOHN, DC;STAGG, RJ;LEWIS, BJ
通讯作者：
LEWIS, BJ
转移性结直肠癌肝切除术的经验：临床和病理危险因素分析。
影响因子：
3.8
作者：
Gayowski,TJ;Iwatsuki,S;Madariaga,JR;Selby,R;Todo,S;Irish,W;Starzl,TE
通讯作者：
Starzl,TE