Monocytes and macrophages in atherogenesis.
Monocytes and macrophages in atherogenesis.
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DOI：
10.1097/mol.0000000000000634
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发表时间：
2019-10
影响因子：
4.4
通讯作者：
Barrett TJ
中科院分区：
文献类型：
--
作者：
Amengual J;Barrett TJ
单核细胞和巨噬细胞在动脉粥样硬化的发病机制中起关键作用，并决定动脉粥样硬化的生长和稳定。髓细胞在代谢和表型功能方面的异质性越来越受到重视。本文综述了最近的单核细胞和巨噬细胞文献，并强调了不同亚群如何促进动脉粥样硬化的发生。单核细胞是在骨髓中产生的短命细胞，释放到循环系统中，在那里它们可以产生炎症细胞因子，重要的是，它们可以分化成长寿的巨噬细胞。在心血管疾病的背景下，存在无数亚型，每种亚型对斑块的发展都有不同的贡献。在这里，我们描述了最近单核细胞和巨噬细胞亚型的新特征，并总结了最近关于骨髓生成介质的文献。对单核细胞和巨噬细胞表型及其分子调节因子的进一步了解可能会转化为新的治疗靶点的开发，以阻止现有斑块的生长或促进斑块的稳定。
Monocytes and macrophages are key players in the pathogenesis of atherosclerosis and dictate atherogenesis growth and stability. The heterogeneous nature of myeloid cells concerning their metabolic and phenotypic function is increasingly appreciated. This review summarizes the recent monocyte and macrophage literature and highlights how differing subsets contribute to atherogenesis. Monocytes are short-lived cells generated in the bone marrow and released to circulation where they can produce inflammatory cytokines and, importantly, differentiate into long-lived macrophages. In the context of cardiovascular disease, a myriad of subtypes, exist with each differentially contributing to plaque development. Herein we describe recent novel characterizations of monocyte and macrophage subtypes and summarize the recent literature on mediators of myelopoiesis. An increased understanding of monocyte and macrophage phenotype and their molecular regulators is likely to translate to the development of new therapeutic targets to either stem the growth of existing plaques or promote plaque stabilization.