Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi.
Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi.
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DOI：
10.1016/j.actatropica.2015.05.007
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发表时间：
2015-11
期刊：
影响因子：
2.7
通讯作者：
Miles MA
中科院分区：
文献类型：
--
作者：
Messenger LA;Miles MA
克氏锥虫的主要繁殖方式是有争议的。田间研究表明，重组是频繁的，非强制性的和特异性的。这些观察结果对T.克鲁兹许多真核病原微生物，以前被假定为克隆繁殖保留了神秘的性周期。克氏锥虫是南美锥虫病的病原体，其主要的繁殖方式仍然是一个有争议的话题。尽管存在两个最近的自然杂交谱系，一个普遍的观点是，重组已被限制在一个进化的规模和流行病学的相关性不大，当代寄生虫种群。本文综述了越来越多的田间研究表明，T。cruzi可能是频繁的、非强制性的和特殊的;可能涉及动基体和核遗传物质的独立交换以及典型的减数分裂机制。这些观察结果对T. cruzi和强调需要进行额外的、密集的和适当抽样的实地调查，辅之以高分辨率的、结合核和线粒体的群体遗传学分析。
The principal reproductive mode of Trypanosoma cruzi is controversial. Field studies indicate recombination is frequent, non-obligatory and idiosyncratic. These observations challenge the paradigm of clonal evolution in T. cruzi. Many eukaryotic pathogenic microorganisms that were previously assumed to propagate clonally have retained cryptic sexual cycles. The principal reproductive mode of Trypanosoma cruzi, the aetiological agent of Chagas disease, remains a controversial topic. Despite the existence of two recent natural hybrid lineages, a pervasive view is that recombination has been restrained at an evolutionary scale and is of little epidemiological relevance to contemporary parasite populations. This article reviews the growing number of field studies which indicate that natural hybridization in T. cruzi may be frequent, non-obligatory and idiosyncratic; potentially involving independent exchange of kinetoplast and nuclear genetic material as well as canonical meiotic mechanisms. Together these observations now challenge the traditional paradigm of preponderate clonal evolution in T. cruzi and highlight the need for additional, intensive and appropriately sampled field surveys, complemented by high resolution, combined nuclear and mitochondrial population genetics analyses.