Diffusional kurtosis imaging in assessing renal function and pathology of IgA nephropathy: a preliminary clinical study Clinical
Diffusional kurtosis imaging in assessing renal function and pathology of IgA nephropathy: a preliminary clinical study Clinical
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弥散峰度成像评估 IgA 肾病肾功能和病理的初步临床研究
DOI：
10.1016/j.crad.2018.05.012
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发表时间：
2018-09-01
影响因子：
2.6
通讯作者：
Chen, L.
中科院分区：
文献类型：
--
作者：
Liu, Y.;Zhang, G-M-Y;Chen, L.
目的：目的：应用弥散峰度成像（DKI）技术评价免疫球蛋白A肾病（IgAN）患者肾纤维化程度。在临床3T磁共振成像（MRI）系统上进行DKI，并进行感兴趣区域测量以确定肾皮质的平均峰度（K）、平均扩散率（D）和表观扩散系数（ADC）。根据肾纤维化的严重程度对肾活检标本进行评分。结果：K值和ADC值不仅与肾小球滤过率呈显著正相关，而且与肾小球硬化指数等纤维化病理评分呈显著正相关（K：r= 0.759，p
AIM: To evaluate renal fibrosis in immunoglobulin A nephropathy (IgAN) using diffusion kurtosis imaging (DKI).MATERIALS AND METHODS: Twenty patients with biopsy-proven IgAN were enrolled. DKI was performed on a clinical 3 T magnetic resonance imaging (MRI) system, and region-ofinterest measurements were conducted to determine mean kurtosis (K), mean diffusivity (D), and apparent diffusion coefficient (ADC) of the kidney cortex. Renal biopsy specimens were scored based on the severity of renal fibrosis. The associations between the DKI data and clinicopathological parameters were investigated.RESULTS: Both the K and ADC were not only well correlated with the estimated glomerular filtration rate, but also significantly associated with the pathological scores of fibrosis, including the glomerular sclerosis index (K: r=0.759, p