Chemistry at the Interface
Chemistry at the Interface
复制标题
界面化学
DOI：
10.1071/ch04180
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发表时间：
2004
影响因子：
1.1
通讯作者：
A. Abell
中科院分区：
文献类型：
--
作者：
A. Abell
最近在纳尔逊举行的新西兰化学研究所（NZIC）会议的主题是“界面上的化学”，这正是十二位全体演讲者，特邀演讲者，部分讲师和数百张海报所呈现的。来自不同化学背景的近400名代表在一个项目中受到了国际和当地演讲者的最佳待遇，该项目提供了对化学未来的一瞥，重要的是，还深入了解了该学科的过去和演变。本期《澳大利亚化学杂志》汇编了一些在会议专题讨论会框架内提出的杰出科学;化学和生物学的界面，界面处的化学技术，化学与商业部门的界面，以及化学与材料和纳米技术的界面（图1）。Bill Denny[1]对靶向肿瘤缺氧的药物设计进行了有见地的讨论。这种肿瘤选择性药物的方法导致了一些国际上重要的发现和对肿瘤生物学的更深入理解。Ted Baker[2]在他的文章中回顾了结构分析领域的最新进展。这项工作突出了分子生物学的进步和X射线晶体学结构测定之间的关键联系。大卫费尔利[3]继续生物学/化学界面的主题，提出了一个杰出的总结，一些极简主义的方法，结构模拟的氨基酸和链，转，螺旋段的蛋白质。加里·埃文斯[4]概述了N-核糖基转移酶过渡态类似物抑制剂的设计和合成及其当前的治疗用途和潜力。这是新西兰药物化学领域的一个真实的成功故事。Andrew阿贝尔及其同事[5]在一篇关于肽醛的合成和抗白内障特性的论文中继续了药物化学主题。会议的一个真正亮点是Dieter Seebach[6]介绍了他在从β和γ-肽中创建新的二级结构方面的开创性工作，这里讨论了这项工作的各个方面。这期特刊还包含两篇论文，介绍了有机和无机化学界面的工作。Peter Steel和同事[7]给出了第一个包含大体积或手性取代基的2，2 ′-联嘧啶配体的例子，Jonathan白色和同事[8]给出了图1。化学家与纳尔逊环境的界面。
The theme for the most recent New Zealand Institute of Chemistry (NZIC) conference held in Nelson was ‘Chemistry at the Interface’ and that’s exactly what the twelve plenary speakers, invited speakers, section lecturers, and hundreds of posters presented. Close to 400 delegates, from a range of chemical backgrounds, were treated to the best of international and local speakers in a programme that provided a glimpse into the future of chemistry and also, importantly, an insight into the discipline’s past and evolution. This issue of theAustralian Journal of Chemistry compiles some of the outstanding science presented within the framework of the conference symposia; the interface of chemistry and biology, techniques of chemistry at the interface, the interface of chemistry with the commercial sector, and the interface of chemistry with materials and nanotechnology (Fig. 1). Bill Denny[1] provides an insightful discussion on the design of drugs that target tumor hypoxia. This approach to tumour-selective agents has lead to some internationally important findings and a deeper understanding of the biology of tumours. Ted Baker[2] reviews recent advances in the area of structural analysis in his article. This work highlights a critical link between advances in molecular biology and in structural determination by X-ray crystallography. David Fairlie[3] continues the theme of the biology/chemistry interface, presenting an outstanding summary of some minimalistic approaches to structural mimetics of amino acids and of strand, turn, and helix segments of proteins. Gary Evans[4] presents an overview on the design and synthesis of transition state analogue inhibitors of N-ribosyl transferases and their current therapeutic uses and potential. This is a real success story in New Zealand-based medicinal chemistry.The medicinal chemistry theme continues in a paper by Andrew Abell and coworkers[5] on the synthesis and anti-cataract properties of peptidic aldehydes. A true highlight of the conference was a presentation by Dieter Seebach[6] on his pioneering work on the creation of new secondary structures derived from βand γ-peptides, and aspects of this work are discussed here. This special issue also contains two papers that present work at the interface of organic and inorganic chemistry. Peter Steel and coworkers[7] present the first examples of 2,2′-bipyrimidine ligands incorporating bulky or chiral substituents, and Jonathan White and coworkers[8] present Fig. 1. The interface of chemists with the Nelson environment.