Postoperative delirium and plasma melatonin
Postoperative delirium and plasma melatonin
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DOI：
10.1054/mehy.1998.0724
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发表时间：
1999-08-01
影响因子：
4.7
通讯作者：
Ishizuka, B
中科院分区：
文献类型：
--
作者：
Uchida, K;Aoki, T;Ishizuka, B
术后神志不清的分子机制尚不清楚。这种情况类似于干扰素治疗或血液透析中的精神症状。我们提出术后精神错乱是由一种重要的神经递质--5-羟色胺缺乏引起的，并回顾了支持我们假设的证据。5-羟色胺缺乏的原因是5-羟色胺前体色氨酸的减少和5-羟色胺代谢物褪黑素的增加。我们的假设可能适用于干扰素治疗和血液透析中精神症状的机制。此外，我们还讨论了动态平衡与生物节律的关系，因为术后妄想可能是一种节律紊乱。
The molecular mechanisms of postoperative delirium are not understood in detail yet. This condition is similar to cases of mental symptoms in interferon therapy or hemodialysis. We propose that postoperative delirium is caused by a deficiency of serotonin, an important neurotransmitter, and review the evidence supporting our hypothesis. The serotonin deficiency results from a decrease in tryptophan, the serotonin precursor, and from an increase in melatonin, a serotonin metabolite. Our hypothesis may be applicable to the mechanisms of mental symptoms in interferon therapy and hemodialysis. In addition, we discuss to the relationship between homeostasis and biorhythms because postoperative delirium may be a dysrhythmia.