Polymers for sustained macromolecule release: procedures to fabricate reproducible delivery systems and control release kinetics.
Polymers for sustained macromolecule release: procedures to fabricate reproducible delivery systems and control release kinetics.
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用于持续大分子释放的聚合物：制造可重复的递送系统和控制释放动力学的程序。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Langer
中科院分区：
文献类型：
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作者：
W. Rhine;D. Hsieh;R. Langer
由乙烯-乙酸乙烯酯共聚物组成的基质是用于持续释放大分子如蛋白质的有用载体。制造这些聚合物输送系统的新方法包括将干燥的粉末状大分子与聚合物溶液混合，并在-80度下浇铸混合物。将所得基质分两个48小时阶段干燥，首先在-20 ℃下，然后在20 ℃下。这些聚合物系统具有均匀的药物分布，并且它们的释放动力学是可重复的。制造参数，如药物粒径，载药量，和基质涂层都显着影响释放动力学。
Matrixes composed of ethylene-vinyl acetate copolymer are useful vehicles for the sustained release of macromolecules such as proteins. A new procedure for fabricating these polymeric delivery systems involved mixing the dry, powdered macromolecule with a polymer solution and casting the mixture at -80 degrees. The resulting matrix was dried in two 48-hr stages, first at -20 degress and then at 20 degrees. These polymer systems had uniform drug distribution, and their release kinetics were reproducible. Fabrication parameters such as drug particle size, drug loading, and matrix coating all significantly affected release kinetics.