Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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DOI：
10.1016/j.jsbmb.2011.05.002
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发表时间：
2011-10-01
影响因子：
4.1
通讯作者：
Rubin, Beverly S.
中科院分区：
文献类型：
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作者：
Rubin, Beverly S.
双酚 A (BPA) 是全球产量最大的化学品之一。这种化合物是通常用于食品和饮料储存的聚碳酸酯塑料的组成部分，BPA 也是用于衬里食品和饮料容器的环氧树脂的成分。研究表明，双酚 A 可以从这些产品以及其他与食品和饮料接触的产品中浸出，因此，推测双酚 A 是常规摄入的。这种化合物也存在于我们每天接触的大量其他产品中，因此在大多数接受检查的个体中检测到这种化合物也就不足为奇了。 BPA 是一种已知的内分泌干扰物。尽管最初被认为是一种弱环境雌激素，但最近的研究表明，BPA 在刺激某些细胞反应方面的效力可能与雌二醇相似。此外，新出现的证据表明 BPA 可能影响多种内分泌相关途径。对啮齿类动物的研究已发现，BPA 水平等于或低于当前可接受的每日摄入量时会产生不利影响。回顾了 BPA 的各种不良反应，并讨论了 BPA 作用的潜在机制。需要进行更多的调查来了解 BPA 暴露对人类的潜在不利健康影响，并了解其可能发挥作用的多种途径。尽管还有许多问题有待解答，但越来越明显的是，双酚 A 的接触是普遍存在的，而且这种内分泌干扰物的影响是复杂而广泛的。 (C) 2011 年，爱思唯尔有限公司出版。
Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. This compound is a building block of polycarbonate plastics often used for food and beverage storage, and BPA is also a component of epoxy resins that are used to line food and beverage containers. Studies have shown that BPA can leach from these and other products in contact with food and drink, and as a result, routine ingestion of BPA is presumed. This compound is also found in an enormous number of other products that we come into contact with daily, and therefore it is not surprising that it has been detected in the majority of individuals examined. BPA is a known endocrine disruptor. Although initially considered to be a weak environmental estrogen, more recent studies have demonstrated that BPA may be similar in potency to estradiol in stimulating some cellular responses. Moreover, emerging evidence suggests that BPA may influence multiple endocrine-related pathways. Studies in rodents have identified adverse effects of BPA at levels at or below the current acceptable daily intake level for this compound. The various reported adverse effects of BPA are reviewed, and potential mechanisms of BPA action are discussed. Much more investigation is needed to understand the potential adverse health effects of BPA exposure in humans and to understand the multiple pathways through which it may act. Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging. (C) 2011 Published by Elsevier Ltd.