Distribution of melanosomes across the retinal pigment epithelium of a hooded rat: implications for light damage.
Distribution of melanosomes across the retinal pigment epithelium of a hooded rat: implications for light damage.
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黑素体在戴帽大鼠视网膜色素上皮上的分布：对光损伤的影响。
DOI：
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发表时间：
1982
影响因子：
4.4
通讯作者：
T. P. Williams
中科院分区：
文献类型：
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作者：
W. L. Howell;L. Rapp;T. P. Williams
在光镜和电镜水平上研究了黑素体在戴帽大鼠（Long-Evans）视网膜色素上皮中的分布。这种分布被证明是不均匀的：更多的黑素体存在于周边比其他地方，重要的是，有非常少的黑素体在一个有限的区域的中央部分的上级半球相比，相应的部分下半球。黑素体最少的区域恰恰是对光损伤高度敏感的区域。因为这一区域在色素眼和白化病眼中是相同的，所以这一区域中黑色素的缺乏不是其对光损伤高度敏感的原因。光线也不会引起黑色素的不均匀分布。一个可能的解释，涉及建议的退化绒毡层，是为了解释黑素体计数和光损伤的敏感性的相关性。
Distribution of melanosomes across the retinal pigment epithelium of hooded rats (Long-Evans) is studied at the light microscopic and electron microscopic levels. This distribution is shown to be nonuniform: more melanosomes exist in the periphery than elsewhere and, importantly, there are very few melanosomes in a restricted area of the central portion of the superior hemisphere compared with the corresponding part of the inferior hemisphere. The region with fewest melanosomes is precisely the one that is highly susceptible to light damage. Because this region is the same in both pigmented and albino eyes, the paucity of melanin in this region is not the cause of its great sensitivity to light damage. Nor does light cause the nonuniform distribution of melanin. A possible explanation, involving a proposed vestigial tapetum, is given in order to explain the correlation of melanosome counts and sensitivity to light damage.